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SML3777

SAR7334

≥98% (HPLC)

Synonym(s):

SAR-7334, 4-({(1R,2R)-2-[(3R)-3-Aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)-3-chlorobenzonitrile, 4-[rac-trans-(1,2)-2-((R)-3-Aminopiperidin-1-yl)indan-1-yloxy]-3-chlorobenzonitrile, SAR 7334

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About This Item

Empirical Formula (Hill Notation):
C21H22ClN3O
CAS Number:
1333210-07-3
Molecular Weight:
367.87
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD27992059
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

Clc1c(ccc(c1)C#N)O[C@H]2[C@@H](Cc4c2cccc4)N3C[C@@H](CCC3)N

InChI key

RLKRLNQEXBPQGQ-OZOXKJRCSA-N

Biochem/physiol Actions

TRPC6-selective transient receptor potential channel (TRPC) inhibitor.



SAR7334 is a TRPC6-selective transient receptor potential channel (TRPC) inhibitor (IC50 against OAG-induced Ca2+ influx in TRPC3/6/7-expressing cells = 9.5/226/282 nM, IC50 >10 μM in TRPC4/10 cells; IC50 = 7.9 nM by whole-cell patch-clamp using TRPC6-HEK-FITR cells).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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