SML3816
Cynandione A
≥98% (HPLC)
Synonym(s):
1-(2′-Acetyl-2,3′,6,6′-tetrahydroxy[1,1′-biphenyl]-3-yl)ethanone
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About This Item
Empirical Formula (Hill Notation):
C16H14O6
CAS Number:
Molecular Weight:
302.28
UNSPSC Code:
51111800
NACRES:
NA.21
InChI
1S/C16H14O6/c1-7(17)9-3-4-12(21)15(16(9)22)14-11(20)6-5-10(19)13(14)8(2)18/h3-6,19-22H,1-2H3
InChI key
DYQDHRLBSZIKEM-UHFFFAOYSA-N
SMILES string
OC1=C(C(O)=CC=C1C(C)=O)C2=C(C=CC(O)=C2C(C)=O)O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Cynandione A is a primary bioactive component of medical plant Cynanchum wilfordii that exhibit neuroprotective and hepatoprotective effects. Cynandione A induces SIRT1 (silent information regulator 2 homolog 1) nuclear translocation through the PKA signaling pathway resulting in beiging (differentiation) in 3T3-L1 cells.
Primary bioactive component of medical plant Cynanchum wilfordii that exhibit neuroprotective and hepatoprotective effects
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
Molecules (Basel), 26(23), 7065-7065 (2021)
Cynandione A inhibits lipopolysaccharide-induced cell adhesion via suppression of the protein expression of VCAM?1 in human endothelial cells
International Journal of Molecular Medicine, 41(3), 1756-1764 (2018)
Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells
European Journal of Pharmacology, 909, 174382-174382 (2021)
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