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SML4102

RG7112

≥98% (HPLC)

Synonym(s):

(4S,5R)-1-[[4-[[4,5-bis(4-chlorophenyl)-2-[4-(tert-butyl)-2-ethoxy-phenyl]-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]]-carbonyl]-4-[3-(methylsulfonyl)propyl]-piperazine, RO 5045337, RO-5045337, RO5045337, RG 7112, RG-7112

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About This Item

Empirical Formula (Hill Notation):
C38H48Cl2N4O4S
CAS Number:
939981-39-2
Molecular Weight:
727.78
MDL number:
MFCD29905459
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

[S](=O)(=O)(CCCN1CCN(CC1)C(=O)N2[C@]([C@](N=C2c5c(cc(cc5)C(C)(C)C)OCC)(C)c4ccc(cc4)Cl)(C)c3ccc(cc3)Cl)C

InChI

1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3/t37-,38+/m0/s1

InChI key

QBGKPEROWUKSBK-QPPIDDCLSA-N

Biochem/physiol Actions

Orally active, potent and selective MDM2 inhibitor with anti-cancer efficacy in cultures and in vivo by induces p53-dependent cell cycle arrest and apoptosis.
RG7112 is an orally active, potent and selective MDM2 inhibitor that binds and blocks p53-binding site (IC50 = 18 nM), thereby induces p53-dependent cell cycle arrest and apoptosis (av GI50 by MTT assays = 0.4 μM/wt 53 vs 33.4 μM/mutant p53) by stabilizing cellular p53. When administered in vivo, RG7112 is efficacious against the growth of tumor xenografts in mice (SJSA-1, SJSA-1luc2, and MHM; 25-200 mg/kg via daily p.o.).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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