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Merck
CN

SML4102

RG7112

≥98% (HPLC)

Synonym(s):

(4S,5R)-1-[[4-[[4,5-bis(4-chlorophenyl)-2-[4-(tert-butyl)-2-ethoxy-phenyl]-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]]-carbonyl]-4-[3-(methylsulfonyl)propyl]-piperazine, RO 5045337, RO-5045337, RO5045337, RG 7112, RG-7112

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About This Item

Empirical Formula (Hill Notation):
C38H48Cl2N4O4S
CAS Number:
939981-39-2
Molecular Weight:
727.78
MDL number:
MFCD29905459
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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SMILES string

[S](=O)(=O)(CCCN1CCN(CC1)C(=O)N2[C@]([C@](N=C2c5c(cc(cc5)C(C)(C)C)OCC)(C)c4ccc(cc4)Cl)(C)c3ccc(cc3)Cl)C

InChI

1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3/t37-,38+/m0/s1

InChI key

QBGKPEROWUKSBK-QPPIDDCLSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Orally active, potent and selective MDM2 inhibitor with anti-cancer efficacy in cultures and in vivo by induces p53-dependent cell cycle arrest and apoptosis.
RG7112 is an orally active, potent and selective MDM2 inhibitor that binds and blocks p53-binding site (IC50 = 18 nM), thereby induces p53-dependent cell cycle arrest and apoptosis (av GI50 by MTT assays = 0.4 μM/wt 53 vs 33.4 μM/mutant p53) by stabilizing cellular p53. When administered in vivo, RG7112 is efficacious against the growth of tumor xenografts in mice (SJSA-1, SJSA-1luc2, and MHM; 25-200 mg/kg via daily p.o.).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000400955
0000400953
0000391385
0000400955
0000400953

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Christian Tovar et al.
Cancer research, 73(8), 2587-2597 (2013-02-13)
MDM2 negatively regulates p53 stability and many human tumors overproduce MDM2 as a mechanism to restrict p53 function. Thus, inhibitors of p53-MDM2 binding that can reactivate p53 in cancer cells may offer an effective approach for cancer therapy. RG7112 is
Binh Vu et al.
ACS medicinal chemistry letters, 4(5), 466-469 (2014-06-06)
The p53 tumor suppressor is a potent transcription factor that plays a key role in the regulation of cellular responses to stress. It is controlled by its negative regulator MDM2, which binds directly to p53 and inhibits its transcriptional activity.
Brian Higgins et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(14), 3742-3752 (2014-05-09)
Antitumor clinical activity has been demonstrated for the MDM2 antagonist RG7112, but patient tolerability for the necessary daily dosing was poor. Here, utilizing RG7388, a second-generation nutlin with superior selectivity and potency, we determine the feasibility of intermittent dosing to

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