Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C21H21F3N2O5
CAS Number:
Molecular Weight:
438.40
MDL number:
NACRES:
NA.21
Product Name
t-TUCB, ≥97% (HPLC), powder, hydrolase (sEH) inhibitor
Quality Level
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Application
t-TUCB may be used in in vitro studies to examine lipid accumulation and its interaction with omega-3 epoxides in regulating autophagy and endoplasmic reticulum (ER) stress markers.
Biochem/physiol Actions
t-TUCB is an orally active and potent soluble epoxide hydrolase (sEH) inhibitor (h/m/r IC50 = 0.9/1.3/16 nM). t-TUCB modulates inflammation and autophagy in adipose tissue and liver in obese fat-1 mice (10 μg/mL in drinking water, ∼1.67 mg/kg/d). When administered at 10 mg/kg via s.c. t-TUCB is substantially more effective than t-AUCB and APAU in a diabetic neuropathy model in rats.
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Cristina López-Vicario et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(2), 536-541 (2015-01-01)
Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits tissue levels of cytochrome P450 (CYP) epoxides derived from omega-6 and omega-3 polyunsaturated fatty acids (PUFA)
Karen Wagner et al.
European journal of pharmacology, 700(1-3), 93-101 (2013-01-02)
Epoxy-fatty acids have been recognized as important cell signaling molecules with multiple biological effects including anti-nociception. The main degradation pathway of these signaling molecules is via the soluble epoxide hydrolase (sEH) enzyme. Inhibitors of sEH extend the anti-nociceptive effects of
Sung Hee Hwang et al.
Journal of medicinal chemistry, 50(16), 3825-3840 (2007-07-10)
A series of N,N'-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane alpha to the urea were prepared and tested as soluble epoxide hydrolase (sEH) inhibitors. This series of compounds showed low nanomolar to picomolar activities against recombinant human sEH.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service