SRE0021
Granzyme B human
recombinant, expressed in insect cells, ≥90% (SDS-PAGE)
Synonym(s):
Granzyme B human, Cytotoxic T-lymphocyte proteinase 2, Granzyme-2, GranzymeB, Lymphocyte protease, SECT, T-cell serine protease 1-3E
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About This Item
UNSPSC Code:
12352204
NACRES:
NA.32
biological source
human
Quality Level
recombinant
expressed in insect cells
Assay
≥90% (SDS-PAGE)
form
lyophilized powder
potency
>0.004 units/mg
specific activity
≥40 units/μg
packaging
pkg of 5 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−70°C
Gene Information
human ... GZMB(3002)
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General description
Granzyme B (GzmB) is a serine protease which is stored in granules of activated cytotoxic T cells and NK cells. GZMB codes for granzyme B.
Biochem/physiol Actions
Granzyme B is considered as the marker of activated CTLs (cytotoxic T-cells), which mediates target-cell apoptosis. It induces apoptosis in caspase-dependent and caspase-independent manner. After contact with target cells, granzyme B is directionally exocytosed, and then enters the target cell with assistance from perforin. Granzyme B specifically cleaves after Asp residues, and particularly processes and activates various pro-caspases. This induces apoptosis in the target cell.
Physical form
Lyophilized powder, containing HEPES buffer (original solution at pH 7.5)
Other Notes
One unit is defined as the amount of enzyme that hydrolyzes 1 pmol/min of IETD-AFC per min at 37°C in 50 mM HEPES, pH 7.5 containing 10 mM CaCl2.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Granzyme B enters the mitochondria in a Sam50-, Tim22-and mtHsp70-dependent manner to induce apoptosis
Chiusolo V, et al.
Cell Death and Differentiation, 24(4), 747-747 (2017)
Risk of generalized vitiligo is associated with the common 55R-94A-247H variant haplotype of GZMB (encoding granzyme B).
Ferrara TM, et al.
The Journal of Investigative Dermatology, 133(6), 1677-1677 (2013)
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