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Merck
CN

SRE0078

Sigma-Aldrich

Aprotinin

≥3 TIU/mg solid, lyophilized powder, ≥96% (HPLC)

Synonym(s):

BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)

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About This Item

Empirical Formula (Hill Notation):
C284H432N84O79S7
CAS Number:
9087-70-1
Molecular Weight:
6511.44
EC Number:
232-994-9
MDL number:
MFCD00130541
UNSPSC Code:
12352202
NACRES:
NA.32

Key Documents

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Product Name

Aprotinin from bovine lung, lyophilized powder, ≥3 TIU/mg solid

biological source

bovine lung

Quality Level

400

description

For research or further manufacturing use only. Not intended for direct use in humans or animals. Non-TSCA use only in US.

Assay

≥96% (HPLC)

form

lyophilized powder

specific activity

≥3 TIU/mg solid

mol wt

~6,500

storage condition

dry at room temperature

color

white

solubility

water: 5 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

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Application

Aprotinin is largely used as an inhibitor of trypsin.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Other Notes

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

低风险生物材料
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Certificates of Analysis (COA)

Lot/Batch Number
0000475031
0000461911
0000461911
0000433592
0000433592

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Articles

Aprotinin Applications in Biotechnology and Pharmaceutical Manufacturing Processes

The Elevate Program offers enhanced quality and documentation attributes for aprotinin, a protease inhibitor used in multiple relevant industries.

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