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SRP0435

Sigma-Aldrich

PDE7B active mouse

recombinant, expressed in baculovirus infected Sf9 cells, ≥65% (SDS-PAGE)

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Synonym(s):
phosphodiesterase 7B
NACRES:
NA.32

biological source

mouse

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥65% (SDS-PAGE)

form

aqueous solution

mol wt

65 kDa

packaging

pkg of 10 μg

NCBI accession no.

NM_013875

UniProt accession no.

Q9QXQ1

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... PDE7B(29863)

General description

Mouse PDE7B (GenBank Accession No. NM_013875) amino acids 108-446 (end) with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Unit Definition

1 unit is defined as the amount of enzyme that will convert 1 pmole of 3?, 5?-cAMP to 5? AMP per min at 30°C.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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E Reyes-Irisarri et al.
Neuroscience, 132(4), 1173-1185 (2005-04-29)
cAMP plays an important role as second messenger molecule controlling multiple cellular processes in the brain. cAMP levels depend critically on the phosphodiesterases (PDE) activity, enzymes responsible for the clearance of intracellular cAMP. We have examined the regional distribution and
C Gardner et al.
Biochemical and biophysical research communications, 272(1), 186-192 (2000-06-29)
We have identified and characterised a novel member of the PDE7 family of cyclic nucleotide phosphodiesterases (PDE), which we have designated PDE7B. Mouse and human full-length cDNAs were isolated encoding a protein of 446 and 450 amino acids, respectively. The
Lingzhi Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(49), 19532-19537 (2008-11-27)
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may contribute to the decreased apoptosis that occurs in chronic lymphocytic leukemia (CLL), we assessed the expression levels of PDE isoforms in

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