SRP3127
NT-1/BCSF-3 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym(s):
Cardiotrophin-like cytokine, Novel Neurtrophin-1/B-Cell Stimulating Factor-3
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (HPLC), ≥98% (SDS-PAGE)
Form:
lyophilized
Mol wt:
22.4 kDa
Impurities:
<0.1 EU/μg endotoxin, tested
biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
mol wt
22.4 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CLCF1(23529)
General description
Novel neurotrophin-1/B-cell stimulating factor-3 (NNT-1/BSF-3), also known as cardiotrophin-like cytokine factor 1 (CLCF1), is encoded by the gene mapped to human chromosome 11q13.2. The encoded protein is a new member of the gp130 cytokine family. Recombinant human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.
Biochem/physiol Actions
Novel neurotrophin-1/B-cell stimulating factor-3 (NNT-1/BSF-3) has neurotrophic and B cell stimulatory effects.In addition, it is also implicated in neuroimmunoendocrine modulation of corticotroph function. BSF-3 helps in the embryonic development and differentiation of motor, sensory and autonomic neurons. It also facilitates the bone formation during development and in the ongoing remodeling of endochondral bone. The encoded protein binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member b (LIFR-b). This ligand and receptor interaction further induces downstream signaling events and activates Janus kinase 1 (JAK1)-signal transducer and activator of transcription protein 3 (STAT3) signaling pathway. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM.
Physical form
Lyophilized with no additives.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Other Notes
MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Cold-induced sweating syndrome including Crisponi syndrome.
Hahn A F and Boman H
GeneReviews(?) (2011)
Novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3) / cardiotrophin-like cytokine (CLC)?a novel gp130 cytokine with pleiotropic functions
George V, et al.
Cytokine & Growth Factor Reviews, 15(5), 325-336 (2004)
G Senaldi et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(20), 11458-11463 (1999-09-29)
We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide
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