SRP5111
p33ING1, His tagged human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
ING1, p24ING1c, p33, p33ING1b, p47, p47ING1a
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~38 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ING1(3621)
General description
p33ING1 displays characteristics of a tumour suppressor protein and can induce cell growth arrest and apoptosis. p33ING1 is a nuclear protein and acute expression of p33 ING1 inhibits cell growth. p33ING1 physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Mutation of p33ING1 gene occurs in neuroblastoma cells and reduced expression is observed in some breast cancer cell lines. It has been proposed that p33ING1 can act as a potent growth regulator in normal and in established cells and plays a role as a candidate tumour suppressor gene whose inactivation may contribute to the development of cancers.
Physical form
Supplied in 50mM MOPS, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation
Garkavtsev
Nature genetics, 23(3), 373-373 (1999-11-05)
Frauke Goeman et al.
Molecular and cellular biology, 25(1), 422-431 (2004-12-17)
ING1 was identified as an inhibitor of growth and has been described as a tumor suppressor. Furthermore, the expression of ING1 is induced in senescent cells and antisense ING1 extends the proliferative life span of primary human fibroblasts. Cooperation of
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