SRP6196
IL-4Rα human
recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE)
Synonym(s):
CD124, IL-4 receptor alpha
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
~24 kDa
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥98% (SDS-PAGE)
form
lyophilized powder
mol wt
~24 kDa
packaging
pkg of 10 and 50 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL4RA(3566)
General description
IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc). The type I receptor contains in addition to the γc an IL-4Rα subunit, where as the type II receptor contains the IL-13Rα. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4Rα is a 209 amino acid protein which corresponds to the entire extracellular domain of IL-4Rα.
Physical form
Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS pH 7.0.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to - 80°C.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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