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SRP6212

Sigma-Aldrich

sDLL-1 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

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Synonym(s):
Delta-1, Delta-like protein 1
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

57-60 kDa

packaging

pkg of 10 μg
pkg of 50 μg

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

O00548

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... DLL-1(28514)

General description

Human sDLL-1 comprises the extracellular signaling domain of DLL-1, a member of a structurally-related family of single-pass type I transmembrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. Recombinant human sDLL-1 is a 57.0-60.0 kDa glycoprotein containing 522 amino-acid residues. The DLL-1 gene is mapped to human chromosome 6q27.

Biochem/physiol Actions

DLL-1 (delta-like ligand 1) functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK (natural killer) cell precursors. Upregulation of DLL-1 was observed in choriocarcinoma and hepatocellular carcinoma.

Physical form

Sterile filtered through a 0.2 micron filter. Lyophilized from 1X PBS, pH 7.5.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Notch receptor?ligand binding and activation: Insights from molecular studies.
Chillakuri C R, et al.
Seminars in Cell & Developmental Biology (2012)
Notch ligand Delta-like 1 as a novel molecular target in childhood neuroblastoma.
Bettinsoli P, et al.
BMC Cancer, 17(1), 352-352 (2017)
Notch receptor?ligand binding and activation: Insights from molecular studies.
Chillakuri C R, et al.
Seminars in Cell & Developmental Biology, 23(4), 421-428 (2012)
Molecular genetics of T cell development.
Rothenberg E V and Taghon T
Annual Review of Immunology, 23 (2005)
Emerging roles of PDGF-D signaling pathway in tumor development and progression.
Wang Z, et al.
Biochimica et Biophysica Acta - Reviews on Cancer, 1806(1), 122-130 (2010)
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