SRP6374
Galectin-9 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
Ecalectin, Gal-9, LGALS9, Tumor antigen HOM-HD-21
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥90% (SDS-PAGE)
Form:
liquid
Mol wt:
18.5 kDa (168 aa, 1-148 aa + His Tag.)
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
18.5 kDa (168 aa, 1-148 aa + His Tag.)
packaging
pkg of 50 μg
concentration
0.5 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... LGALS9(3965)
General description
Galectin-9 (Gal-9) is a member of animal lectins that have an affinity to β-galactosides and Forssman pentasaccharide. It is strongly overexpressed in Hodgkin′s disease tissue and it might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency. Recombinant Galectin-9 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Physical form
0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM NaCl and 20% glycerol.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Gaia Nebbia et al.
PloS one, 7(10), e47648-e47648 (2012-11-01)
The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in
Si-Na Kim et al.
Immune network, 15(5), 241-251 (2015-11-12)
Bone marrow-derived mesenchymal stem cells (MSCs) have immunomodulatory properties and can suppress exaggerated pro-inflammatory immune responses. Although the exact mechanisms remain unclear, a variety of soluble factors are known to contribute to MSC-mediated immunosuppression. However, functional redundancy in the immunosuppressive
Rina Nakajima et al.
Journal of dermatological science, 96(3), 134-142 (2019-12-04)
Galectin-9, a member of the galectin family, can promote tumor growth through inducing apoptosis in anti-tumor immune cells via T cell immunoglobulin and mucin domain 3 (TIM-3). On the other hand, galectin-9 also induces tumor cell apoptosis in many malignancies
Gisela M Vaitaitis et al.
PloS one, 7(6), e38708-e38708 (2012-06-12)
While it has long been understood that CD40 plays a critical role in the etiology of autoimmunity, glycobiology is emerging as an important contributor. CD40 signaling is also gaining further interest in transplantation and cancer therapies. Work on CD40 signaling
Judith Leitner et al.
PLoS pathogens, 9(3), e1003253-e1003253 (2013-04-05)
T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein that was originally identified as a marker for murine T helper type 1 cells. TIM-3 was found to negatively regulate murine T cell responses and
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