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SRP6529

Sigma-Aldrich

NAD Kinase human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

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Synonym(s):
EC 2.7.1.23, NADK, Poly (P)/ATP NAD Kinase

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

liquid

mol wt

monomer ~50 kDa (monomer.Human full length NAD kinase aa 1- 446 is fused at the N-terminus to a His-tag.)

packaging

pkg of 10 μg

concentration

1 mg/mL

UniProt accession no.

O95544

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NADK(65220)

General description

NAD kinase is localized to mitochondria and cytosol. The gene is mapped to human chromosome 1p36.33.

Biochem/physiol Actions

NAD kinase EC 2.7.1.23 catalyzes the transfer of a phosphate group from ATP to NAD+ to generate NADP+, which acts as an electron donor for biosynthetic reactions upon reduction. NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis.

Physical form

1 mg/mL of ammonium sulphate suspension.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Enzymology of NAD+ homeostasis in man.
Magni G, et al.
Cellular and Molecular Life Sciences, 61(1), 19-34 (2004)
Significance of Ser-188 in human mitochondrial NAD kinase as determined by phosphomimetic and phosphoresistant amino-acid substitutions.
Kawabata Y, et al.
Biochemical and Biophysical Research Communications, 468(4), 691-695 (2015)
Leonardo A Meza-Zepeda et al.
Journal of cellular and molecular medicine, 12(2), 553-563 (2008-04-19)
The potential use of human mesenchymal stem cells for therapeutic applications implies large scale in vitro culture, increasing the probability of genetic instability and transformation. We examine here the incidence of unbalanced and balanced chromosome rearrangements in polyclonal and single

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