SRP6529
NAD Kinase human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
EC 2.7.1.23, NADK, Poly (P)/ATP NAD Kinase
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About This Item
NACRES:
NA.54
UNSPSC Code:
12352204
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥95% (SDS-PAGE)
Form:
liquid
Mol wt:
monomer ~50 kDa (monomer.Human full length NAD kinase aa 1- 446 is fused at the N-terminus to a His-tag.)
biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
monomer ~50 kDa (monomer.Human full length NAD kinase aa 1- 446 is fused at the N-terminus to a His-tag.)
packaging
pkg of 10 μg
concentration
1 mg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... NADK(65220)
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General description
NAD kinase is localized to mitochondria and cytosol. The gene is mapped to human chromosome 1p36.33.
Biochem/physiol Actions
NAD kinase EC 2.7.1.23 catalyzes the transfer of a phosphate group from ATP to NAD+ to generate NADP+, which acts as an electron donor for biosynthetic reactions upon reduction. NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis.
Physical form
1 mg/mL of ammonium sulphate suspension.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Enzymology of NAD+ homeostasis in man.
Magni G, et al.
Cellular and Molecular Life Sciences, 61(1), 19-34 (2004)
Significance of Ser-188 in human mitochondrial NAD kinase as determined by phosphomimetic and phosphoresistant amino-acid substitutions.
Kawabata Y, et al.
Biochemical and Biophysical Research Communications, 468(4), 691-695 (2015)
Leonardo A Meza-Zepeda et al.
Journal of cellular and molecular medicine, 12(2), 553-563 (2008-04-19)
The potential use of human mesenchymal stem cells for therapeutic applications implies large scale in vitro culture, increasing the probability of genetic instability and transformation. We examine here the incidence of unbalanced and balanced chromosome rearrangements in polyclonal and single
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