SRP8027
CD24 (mouse): FC (human)
recombinant, expressed in HEK 293 cells, >90% (SDS-PAGE)
Synonym(s):
M1/69-J11D heat stable antigen, NaMN adenylyltransferase 1, Nectadrin, X62 Heat stable antigen (HSA)
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
>90% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in HEK 293 cells
Mol wt:
~50 kDa by SDS-PAGE
biological source
mouse
recombinant
expressed in HEK 293 cells
assay
>90% (SDS-PAGE)
form
lyophilized
mol wt
~50 kDa by SDS-PAGE
packaging
pkg of 50 μg
impurities
<0.06 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... CD24(100133941)
General description
CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. Widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).
Physical form
Lyophilized from PBS.
Preparation Note
Reconstitute with 50 μL deionized water.
Other Notes
Mouse CD24 (aa 27-52) is fused at the C-terminus to the Fc portion of human IgG1.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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