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U211200

DMT-2′Fluoro-dU Phosphoramidite

Name: DMT-2′Fluoro-dU Phosphoramidite
Brand: SIGMA

≥99.0% (reversed phase HPLC)

Synonym(s):

DMT-2′-Fluoro-dU amidite

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About This Item

Empirical Formula (Hill Notation):

C₃₉H₄₆FN₄O₈P

CAS Number:

146954-75-8

Molecular Weight:

748.78

NACRES:

NA.51

PubChem Substance ID:

329827613

UNSPSC Code:

41116105

MDL number:

MFCD11113919

Assay:

≥99% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

Biological source:

non-animal source (no BSE/TSE risk)

Form:

powder

Storage temp.:

−20°C

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Properties

biological source

non-animal source (no BSE/TSE risk)

Quality Level

300

product line

Proligo Reagents

assay

≥99% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

form

powder

mol wt

748.78 g/mol

technique(s)

oligo synthesis: suitable

impurities

≤0.3% water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (³¹P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3% residual Solvent content

color

white to off-white

λ

conforms (UV/VIS Identity)

suitability

conforms to structure for H-NMR, conforms to structure for LC-MS

nucleoside profile

base: deoxyuridine
base protecting group: none
2' protecting group: fluoro
5' protecting group: DMT
deprotection: fast/standard

storage temp.

−20°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](F)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(=O)NC3=O)(c4ccccc4)c5ccc(OC)cc5

InChI

1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35-,36-,37-,53?/m1/s1

InChI key

HQHQPAYRJJMYQX-DJTPZYMWSA-N

Description

General description

DMT-2′Fluoro-dU Phosphoramidite is a 2′Fluoro phosphoramidite that is used to synthesize oligonucleotides that are more thermally stable and provide increased nuclease resistance.

Its key features are-

Can be employed together with DNA or RNA phosphoramidites
Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA for 10 minutes at 65 °C
Synthesis of 2′Fluoro oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 3 minutes compared to 90 seconds for DNA monomers)
Consistent lot-to-lot high purity and performance
Manufactured under a certified ISO 9001 quality system

Application

DMT-2′Fluoro-dU Phosphoramidite is suitable for use in the synthesis of 2′-fluoro modified oligonucleotide sequences by employing automated solid-phase chemistry.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Global Trade Item Number

SKU	GTIN
U211200-500G	04061832026343
U211200-C	04061826593479
U211200-AVC	04061826593462
U211200-AGL	04061826593455
U211200-100G	04061833318003