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58979C30

SUPELCOSIL^™ LC-CN (3 µm) HPLC Columns

Name: SUPELCOSIL<SUP>&#8482;</SUP> LC-CN (3 µm) HPLC Columns
Brand: SUPELCO

L × I.D. 3.3 cm × 3 mm, HPLC Column

Synonym(s):

Cyanopropyl HPLC Column

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About This Item

UNSPSC Code:

41115700

eCl@ss:

32110501

NACRES:

SB.52

L × i.d.:

3.3 cm × 3 mm

Particle size:

3 μm

Matrix active group:

cyano phase

Pore size:

120 Å

Matrix:

silica gel, spherical particle platform, fully porous particle

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Properties

Product Name

SUPELCOSIL^™ LC-CN HPLC Column, 3 μm particle size, L × I.D. 3.3 cm × 3 mm

material

stainless steel column

Quality Level

100

agency

suitable for USP L10

product line

SUPELCOSIL^™

feature

endcapped

manufacturer/tradename

SUPELCOSIL^™

packaging

1 ea of

extent of labeling

4% Carbon loading

parameter

≤70 °C temp. range, 400 bar pressure (5801 psi)

technique(s)

HPLC: suitable

L × I.D.

3.3 cm × 3 mm

surface area

170 m²/g

surface coverage

surface coverage 3.5 μmol/m²

matrix

silica gel, spherical particle platform, fully porous particle

matrix active group

cyano phase

particle size

3 μm

pore size

120 Å

pH range

2-7.5

application(s)

food and beverages

separation technique

hydrophilic interaction (HILIC), normal phase, reversed phase

Description

General description

The LC-CN phase is often used as a substitute for silica because it offers the advantages of a bonded phase (such as quick equilibration, and less sensitivity to small changes of the water content in the mobile phase). More often, however, the LC-CN column is operated under reversed-phase mobile phase conditions.

Application

Validated Simple HPLC-UV Method for Mycophenolic Acid (MPA) Monitoring in Human Plasma. Internal Standardization: : This study presents a validated HPLC-UV method for monitoring Mycophenolic Acid in human plasma, emphasizing the role of internal standardization in accuracy and precision of the results. The SUPELCOSIL^™ LC-CN HPLC column was utilized for its effective separation capabilities (Kunicki and Wróbel, 2021).

An Improved HPLC Method for Therapeutic Drug Monitoring of Daunorubicin, Idarubicin, Doxorubicin, Epirubicin, and Their 13-Dihydro Metabolites in Human Plasma: This paper details an enhanced HPLC method for monitoring various anthracycline drugs in human plasma. The use of the SUPELCOSIL^™ LC-CN HPLC column improved the detection and quantification of these drugs and their metabolites (Fogli et al., 1999).

Analysis of Diltiazem and Desacetyldiltiazem in Serum by High-Performance Liquid Chromatography: This research focused on developing a precise HPLC method to analyze diltiazem and its metabolite in serum, employing the SUPELCOSIL^™ LC-CN HPLC column for effective separation and detection (Paczkowski et al., 1995).

High-Performance Liquid Chromatographic Method for the Determination of Eclanamine and Its N-Desmethyl and N,N-Didesmethyl Metabolites in Urine: This study describes a robust HPLC method for determining eclanamine and its metabolites in urine, utilizing the SUPELCOSIL^™ LC-CN HPLC column for its high-resolution capabilities (Lakings et al., 1988).

Other Notes

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

SUPELCOSIL is a trademark of Sigma-Aldrich Co. LLC

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An improved HPLC method for therapeutic drug monitoring of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites in human plasma.

S Fogli et al.

Therapeutic drug monitoring, 21(3), 367-375 (1999-06-12)

A single high-performance liquid chromatography (HPLC) method, suitable for the analysis of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites is validated in the present study. Preparation of plasma samples was performed by a first extraction of analytes with a

Automated in-tube solid-phase microextraction-liquid chromatography-electrospray ionization mass spectrometry for the determination of ranitidine.

H Kataoka et al.

Journal of chromatography. B, Biomedical sciences and applications, 731(2), 353-359 (1999-10-08)

The technique of automated in-tube solid-phase microextraction (SPME) coupled with liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) was evaluated for the determination of ranitidine. In-tube SPME is an extraction technique for organic compounds in aqueous samples, in which analytes are extracted

Simple and rapid determination of amphetamine, methamphetamine, and their methylenedioxy derivatives in urine by automated in-tube solid-phase microextraction coupled with liquid chromatography-electrospray ionization mass spectrometry.