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Merck
CN

80023449

TSKgel® UP-SW3000 (2 µm) HPLC Columns

L x I.D. 15 cm × 4.6 mm, diol phase

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About This Item

UNSPSC Code:
41115700
NACRES:
NB.21

Key Documents

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Product Name

TSKgel® UP-SW3000 HPLC Column, phase diol, L × I.D. 15 cm × 4.6 mm, 2 μm particle size

material

stainless steel

Agency

suitable for USP L20
suitable for USP L59

product line

TSKgel®

manufacturer/tradename

Tosoh 0023449

parameter

≤0.5 M salt concentration
0-30% aqueous soluble organic solvents
0.35 mL/min flow rate
10-30 °C temp. range
340 bar pressure

technique(s)

HPLC: suitable

L × I.D.

15 cm × 4.6 mm

matrix

silica particle platform

matrix active group

diol phase

particle size

2 μm

pore size

250 Å

pH range

2.5-7.5

separation technique

size exclusion (SEC)

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Application

TSKgel® UP-SW3000 HPLC Column may be used for the separation of:
  • Free payloads and related species from antibody drug conjugates (ADCs) and their aggregates, during their determination by using 1-dimensional (1D) gradient size exclusion chromatography (SEC).
  • Protein biopharmaceuticals in aqueous solutions, during their analysis by SEC.

Other Notes

Related Catagories: Analytical/Chromatography, HPLC, HPLC & FPLC Columns for Biopolymer Separations, TSKgel Gel Filtration Columns for Proteins and Other Biopolymers, TSKgel Gel Filtration Columns to Analyze Purity and Aggregates, TSKgel Size Exclusion Columns
Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

TSKgel is a registered trademark of Tosoh Corporation

Regulatory Information

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Comprehensive study on the effects of sodium and potassium additives in size exclusion chromatographic separations of protein biopharmaceuticals.
Goyon A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 144, 242-251 (2017)
Extending the limits of size exclusion chromatography: Simultaneous separation of free payloads and related species from antibody drug conjugates and their aggregates.
Goyon A, et al.
Journal of Chromatography A, 1539, 19-29 (2018)

Articles

Analytical SEC Columns for Biomolecule Separations

Size exclusion chromatography columns enhance biomolecule separation efficiency with sub-2 μm particles, improving analytical performance.

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