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Merck
CN

BP836

Venlafaxine impurity standard

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

Venlafaxine hydrochloride, (+/-)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride, Effexor

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About This Item

Empirical Formula (Hill Notation):
C17H27NO2 · HCl
CAS Number:
99300-78-4
Molecular Weight:
313.86
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD03658865

Key Documents

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InChI

1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

SMILES string

Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2

InChI key

QYRYFNHXARDNFZ-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

venlafaxine

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

application(s)

pharmaceutical
pharmaceutical small molecule

format

mixture

storage temp.

2-8°C

Gene Information

human ... SLC6A2(6530), SLC6A4(6532)

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Venlafaxine impurity standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Venlafaxine Tablets
  • Venlafaxine Prolonged-release Tablets
  • Venlafaxine Prolonged-release Capsules

    • Biochem/physiol Actions

    Venlafaxine is a dual serotonin-noradrenaline reuptake inhibitor that displays Ki values of 82 and 2480 nM respectively. It is a general class antidepressant.
    Venlafaxine is an antidepressant. The mechanism of the antidepresant action of venlafaxine in humans is associated with its potentiation of neurotransmitter activity in the CNS. Venlafaxine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitor of dopamine reuptake. Venlafaxine has no significant activity for muscarinic, histaminergic, or α-1 adrenergic receptors in vitro. Venlafaxine does not possess MAO inhibitor activity.

    Packaging

    Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

    pictograms

    Environment
    GHS09

    hcodes

    H411

    Hazard Classifications

    Aquatic Chronic 2

    Storage Class

    11 - Combustible Solids

    wgk

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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