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Merck
CN

PHL84241

Mogrol

phyproof® Reference Substance

Synonym(s):

(3β,9β,10α,11α,24R)-9-Methyl-19-norlanost-5-ene-3,11,24,25-tetrol

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About This Item

Empirical Formula (Hill Notation):
C30H52O4
CAS Number:
Molecular Weight:
476.73
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
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grade

primary reference standard

product line

phyproof® Reference Substance

assay

≥90.0% (HPLC)

form

solid

manufacturer/tradename

PhytoLab

SMILES string

O[C@H]1[C@@]2([C@H]([C@]4([C@@]([C@H](CC4)[C@@H](CC[C@@H](O)C(O)(C)C)C)(C1)C)C)CC=C3[C@H]2CC[C@@H](C3(C)C)O)C

InChI

1S/C30H52O4/c1-18(9-13-24(32)27(4,5)34)19-15-16-28(6)22-12-10-20-21(11-14-23(31)26(20,2)3)30(22,8)25(33)17-29(19,28)7/h10,18-19,21-25,31-34H,9,11-17H2,1-8H3/t18-,19-,21-,22+,23+,24-,25-,28+,29-,30+/m1/s1

InChI key

JLYBBRAAICDTIS-AYEHCKLZSA-N

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. K

Biochem/physiol Actions

Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells.
aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities; suppresses adipocyte differentiation

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG


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Storage Class

11 - Combustible Solids

wgk

WGK 3



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Global Trade Item Number

SKUGTIN
PHL84241-10MG04061842166343