Our wide range of cell culture supplements is designed with one goal in mind: to help grow your success. All over the world, biopharmaceutical companies rely on our products to satisfy the fundamental nutrition needs of cell culture processes, knowing from experience that our quality products and expertise can help them improve productivity and stability, while mitigating risk.
CellPrime® rAlbumin is a GMP-manufactured, non-animal origin (NAO) recombinant media supplement, ensuring excellent quality, superior performance, and lot-to-lot consistency. It is expressed from a synthetic DNA insert encoding the human albumin gene sequence in the yeast Pichia pastoris, and like all recombinant CellPrime® products, it does not contain components of animal or human origin throughout its manufacturing process.
Insulin plays a critical role in mammalian cell culture biomanufacturing, enhancing cell growth, protein production, and long-term viability of various cell lines. It is a pivotal component in upstream media formulations for the production of monoclonal antibody therapeutics, viral vaccines, and various recombinant biomolecules such as coagulation factors.
Pancreatic trypsin, a ~23 kD serine protease, has been crucial in stem cell propagation, vaccine manufacturing, and precursor maturation in therapeutic recombinant insulin production as a dissociation agent and manufacturing aid. It specifically cleaves the peptide backbone after arginine or lysine residues.
A proprietary recombinant trypsin alternative has been added to the CellPrime® portfolio to meet the increased market demand for non-animal origin cell culture reagents, ensuring a safe and sustainable supply for stem cell propagation and addressing the risk of introducing adventitious viral agents into the manufacturing process.
CellPrime® rTrypsin is a non-animal origin product, recombinantly expressed from a synthetic DNA construct encoding the porcine gene sequence in the yeast Pichia pastoris. It does not contain components of animal origin throughout its manufacturing process, from the Master Cell Bank (MCB) and Working Cell Bank (WCB) to the final product.
CellPrime® rTransferrin AF is designed for industrial cell culture applications, aiming to facilitate extracellular iron binding and transport, thereby promoting viability and proliferation in cells grown in serum-free media. It offers the advantages of natural plasma-derived transferrin while ensuring non-animal origin compliance.
The increasing demand for biotherapeutics as well as healthcare cost pressures have spurred an intense search for more cost effective, faster and more efficient alternative expression systems.
All our recombinant, non-animal origin (NAO) supplements are specifically formulated for cell culture applications. Recombinant manufacturing in state-of-the-art, cGMP production facilities ensures reliable and consistent supply, while also supporting simplified regulatory processes. You will find an industry-leading selection of recombinant supplements and process enzymes for your specific application, including:
As part of our comprehensive portfolio, we also offer animal-derived cell culture supplements used globally in diagnostics and numerous commercial biopharmaceutical products. While mammalian cells can be challenging to work with from a bioprocessing perspective, our experience and stringent product quality help you tackle complex processing and scale-up parameters with confidence.
In addition, we produce a variety of complementary products for specific cell culture and in vitro diagnostics (IVD) applications. Products such as bovine transferrin, EX-CYTE®, and bovine gamma globulin, for example, are specifically designed and produced to meet the quality and documentation needs of customers operating in a regulated environment.
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