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Showing 1-30 of 3711 results for "34860" within Papers
Yeong Hun Song et al.
Biological & pharmaceutical bulletin, 37(6), 1021-1028 (2014-06-03)
Tribulus terrestris fruits are well known for their usage in pharmaceutical preparations and food supplements. The methanol extract of T. terrestris fruits showed potent inhibition against the papain-like protease (PLpro), an essential proteolylic enzyme for protection to pathogenic virus and
Zong-Ping Zheng et al.
Journal of agricultural and food chemistry, 63(5), 1615-1621 (2015-01-21)
Norartocarpetin is a flavone widely distributed in Moraceae plants with strong tyrosinase inhibitory activity. However, its poor solubility in aqueous systems and in food grade solvents (oils) limits its extensive applications. The aim of this study was to improve the
H Khan et al.
Journal of drug targeting, 22(9), 790-795 (2014-06-04)
The work presented demonstrates an unconventional approach in the preparation of smart microneedle (MN) coatings utilising electrohydrodynamic atomisation (EHDA) principles. Stainless steel (600-900 µm in height) MNs were coupled to a ground electrode (in the EHDA coating set-up) with the
Chunyan Zhao et al.
European journal of drug metabolism and pharmacokinetics, 39(2), 129-137 (2013-06-12)
For orally administered drugs, the metabolism of a drug by the gut flora plays an important role in the bioavailability, activation and disposition of the drug in vivo. However, no in vitro system is currently available to evaluate the metabolism
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in
Nanami Sato et al.
Developmental cell, 59(10), 1252-1268 (2024-04-06)
The blueprint of the mammalian body plan is laid out during gastrulation, when a trilaminar embryo is formed. This process entails a burst of proliferation, the ingression of embryonic epiblast cells at the primitive streak, and their priming toward primitive
Anna Vallverdú-Queralt et al.
Journal of agricultural and food chemistry, 63(1), 142-149 (2014-12-03)
A novel, robust and fast ultrahigh performance liquid chromatography–multiple reaction monitoring mass spectrometry method has been developed for the simultaneous quantification of reduced glutathione (GSH), oxidized glutathione (GSSG), grape reaction product (GRP) and hydroxycinnamic acids in wine. The method was
Hongmei Hu et al.
Journal of chromatographic science, 52(5), 375-382 (2013-05-07)
A simple, rapid, sensitive and high throughput method is described, based on solid-phase disk extraction (SPDE) and gas chromatography-electron capture detection, for the determination of chlorobenzens (CBs) in water samples. The proposed SPDE sample pretreatment method was initially optimized and
Gunwoo Kim et al.
Journal of the American Chemical Society, 137(11), 3867-3876 (2015-03-04)
(17)O NMR spectroscopy combined with first-principles calculations was employed to understand the local structure and dynamics of the phosphate ions and protons in the paraelectric phase of the proton conductor CsH2PO4. For the room-temperature structure, the results confirm that one
Jagdeep S Walia et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(3), 414-422 (2014-12-18)
G(M2) gangliosidoses are severe neurodegenerative disorders resulting from a deficiency in β-hexosaminidase A activity and lacking effective therapies. Using a Sandhoff disease (SD) mouse model (Hexb(-/-)) of the G(M2) gangliosidoses, we tested the potential of systemically delivered adeno-associated virus 9
Jian-Zhong Chen et al.
Journal of pharmaceutical and biomedical analysis, 95, 158-163 (2014-04-01)
Mifepristone (RU486) is a chemical abortifacient used by hundreds of millions of women world-wide. It has recently been used in clinical trials for psychotic depression and cancer chemotherapy. Metapristone is the most predominant biological active metabolite of mifepristone, and being
Su Liang et al.
Biomedical chromatography : BMC, 29(4), 570-577 (2014-08-29)
Altered serum proline levels are related to cancer metabolism. This study developed and validated a LC-MS/MS method to analyze proline in human serum. Surrogate blank serum, coupled with stable isotope l-proline-(13) C5 ,(15) N as internal standard, was used for
Hua Zhang et al.
Drug delivery, 21(8), 588-594 (2013-12-11)
Low dissolution rate of a poorly water soluble drug often leads to low and variable oral bioavailability. Formulating drugs as nanocrystals can help to overcome these problems by increasing the solubility and dissolution velocity. But different preparation approaches may result
Run-Zhang Shi et al.
Clinica chimica acta; international journal of clinical chemistry, 441, 99-104 (2014-12-30)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides sensitivity and specificity for monitoring tacrolimus drug level in blood, but it requires an LC system and sample preparation, which is not amenable to random access testing typical of immunoassays. Paper spray (PS) ionization
Yang Zhao et al.
Journal of pharmaceutical and biomedical analysis, 107, 251-257 (2015-01-27)
A flow-injection mass spectrometric metabolic fingerprinting method in combination with chemometrics was used to differentiate Aurantii Fructus Immaturus from its counterfeit Poniciri Trifoliatae Fructus Immaturus. Flow-injection mass spectrometric (FIMS) fingerprints of 9 Aurantii Fructus Immaturus samples and 12 Poniciri Trifoliatae
Nadège Minois et al.
PloS one, 9(7), e102435-e102435 (2014-07-11)
Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating
Alejandra Nieto et al.
Investigative ophthalmology & visual science, 56(2), 1070-1080 (2015-01-24)
To understand the relationship between rapamycin loading/release and surface chemistries of porous silicon (pSi) to optimize pSi-based intravitreal delivery system. Three types of surface chemical modifications were studied: (1) pSi-COOH, containing 10-carbon aliphatic chains with terminal carboxyl groups grafted via
Rong Zhang et al.
Journal of chromatography. A, 1362, 168-179 (2014-08-28)
It has been reported that HILIC column chemistry has a great effect on the number of detected metabolites in LC-HRMS-based untargeted metabolite profiling studies. However, no systematic investigation has been carried out with regard to the optimisation of mobile phase
Carolin Bock et al.
Journal of cancer research and clinical oncology, 140(11), 1873-1881 (2014-06-26)
Epithelial mesenchymal transition is a major mechanism to explain metastatic events in breast cancer. Another important aspect is that cells with stem cell properties are able to become resistant against chemotherapeutics. Our main goal was to investigate the role of
Paola Quifer-Rada et al.
Food chemistry, 169, 336-343 (2014-09-23)
Beer is the second most consumed alcoholic beverage in Europe and shown by the European Prospective Investigation into Cancer and Nutrition cohort study to be the main food contributor to hydroxybenzoic acid intake. About 70-80% of the total polyphenol content
Bernhard Kluger et al.
Analytical chemistry, 86(23), 11533-11537 (2014-11-06)
An untargeted metabolomics workflow for the detection of metabolites derived from endogenous or exogenous tracer substances is presented. To this end, a recently developed stable isotope-assisted LC-HRMS-based metabolomics workflow for the global annotation of biological samples has been further developed
Regina C Betz et al.
Nature communications, 6, 5966-5966 (2015-01-23)
Alopecia areata (AA) is a prevalent autoimmune disease with 10 known susceptibility loci. Here we perform the first meta-analysis of research on AA by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a
Matthew N Newmeyer et al.
Journal of chromatography. A, 1358, 68-74 (2014-07-30)
Methamphetamine is a widely abused psychostimulant containing a chiral center. Consumption of over-the-counter and prescription medications may yield positive amphetamines results, but chiral separation of l- and d-methamphetamine and its metabolite amphetamine can help determine whether the source was licit
Ido Sagi et al.
Cell stem cell, 25(3), 419-432 (2019-09-07)
Genomic imprinting is an epigenetic mechanism that results in parent-of-origin monoallelic expression of specific genes, which precludes uniparental development and underlies various diseases. Here, we explored molecular and developmental aspects of imprinting in humans by generating exclusively paternal human androgenetic
Anna Chiara Vicini et al.
Nature protocols, 16(12), 5559-5591 (2021-11-12)
Fluorine is a key element present in ~35% of agrochemicals and 25% of marketed pharmaceutical drugs. The availability of reliable synthetic protocols to prepare catalysts that allow the efficient incorporation of fluorine in organic molecules is therefore essential for broad
Wen Hu et al.
Colloids and surfaces. B, Biointerfaces, 123, 254-263 (2014-10-04)
Nanocarriers with low toxicity, high stability, long circulation in blood and triggered drug release at target sites are extremely needed for cancer therapy. In this study, different molar ratios of poly (ethylene glycol) (PEG) were conjugated to poly (amidoamine) dendrimer
Chenqi Zhao et al.
Biochemical pharmacology, 90(1), 62-72 (2014-05-06)
Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS). In those cells LPA was reported to
Ewa Bulska et al.
Journal of pharmaceutical and biomedical analysis, 106, 159-166 (2014-12-17)
The contamination of commonly used supplements by unknown steroids as well as their metabolites (parent compounds) become a challenge for the analytical laboratories. Although the determination of steroids profile is not trivial because of the complex matrix and low concentration
George Cruzan
Critical reviews in toxicology, 39(4), 347-363 (2009-06-12)
There are no published cancer studies of methanol-exposed cohorts. Genotoxicity studies do not suggest carcinogenic activity from methanol exposure. Oncogenicity studies of methanol were conducted by inhalation for approximately 20 hrs/day at up to 1000 ppm in F344 rats and
Rahul Narayanan et al.
Angewandte Chemie (International ed. in English), 53(23), 5936-5940 (2014-03-20)
Ambient ionization is achieved by spraying from a carbon nanotube (CNT)-impregnated paper surface under the influence of small voltages (≥3 V). Organic molecules give simple high-quality mass spectra without fragmentation in the positive or negative ion modes. Conventional field ionization is
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