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Showing 1-30 of 43 results for "D1446" within Papers
Shiwei Deng et al.
British journal of pharmacology, 172(9), 2246-2257 (2014-12-19)
The catalytic topoisomerase II inhibitor dexrazoxane has been associated not only with improved cancer patient survival but also with secondary malignancies and reduced tumour response. We investigated the DNA damage response and the role of the activating transcription factor 3
Dana M Walker et al.
Pediatric blood & cancer, 60(4), 616-620 (2012-09-06)
Acute lymphoblastic (ALL) and myeloid leukemia (AML) account for approximately 26% of pediatric cancers. Anthracyclines are widely used to treat these leukemias, but dosing is limited by cardiotoxicity. Data support the efficacy of dexrazoxane as a cardioprotectant in children; however
Annie Calvé et al.
American journal of physiology. Heart and circulatory physiology, 302(10), H2048-H2057 (2012-03-27)
The impact of cancer therapies on adult cardiac function is becoming a concern as more children survive their initial cancer. Cardiovascular disease is now a significant problem to adult survivors of childhood cancer. Specifically, doxorubicin (DOX) may be particularly harmful
Andrés Herrero-Ruiz et al.
Cell reports, 35(2), 108977-108977 (2021-04-15)
Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. Topoisomerases are therefore considered positive facilitators
Plasmodium falciparum and Plasmodium yoelii: Effect of the Iron Chelation Prodrug Dexrazoxane onin VitroCultures
Loyevsky M, et al.
Experimental Parasitology, 91(2), 105-114 (1999)
Tao Yue et al.
Langmuir : the ACS journal of surfaces and colloids, 32(7), 1909-1919 (2016-01-08)
Contrary to the well-studied dynamics and mechanics at organ and tissue levels, there is still a lack of good understanding for single cell dynamics and mechanics. Single cell dynamics and mechanics may act as an interface to provide unique information
Viktoryia Sidarovich et al.
Molecular pharmacology, 87(3), 513-524 (2015-01-08)
Iron is an essential cellular nutrient, being a critical cofactor of several proteins involved in cell growth and replication. Compared with normal cells, neoplastic cells have been shown to require a greater amount of iron, thus laying the basis for
Petra Kovarikova et al.
Journal of pharmaceutical and biomedical analysis, 76, 243-251 (2013-01-24)
Dexrazoxane (DEX) is the only clinically used drug effective against anthracycline-induced cardiotoxicity and extravasation injury. However, the mechanism of its cardioprotective action still remains elusive. This paucity of comprehensive data is at least partially caused by the analytical difficulties associated
Jan Neckář et al.
Canadian journal of physiology and pharmacology, 90(9), 1303-1310 (2012-08-24)
Dexrazoxane (DEX), an inhibitor of topoisomerase II and intracellular iron chelator, is believed to reduce the formation of reactive oxygen species (ROS) and protects the heart from the toxicity of anthracycline antineoplastics. As ROS also play a role in the
Minh C Vuong et al.
Mutation research, 750(1-2), 63-71 (2012-09-25)
ICRF-154 and bimolane have been used for the treatment of cancer, psoriasis, and uveitis in humans. Previous reports have revealed that the two drugs are topoisomerase II catalytic inhibitors, and patients treated with these agents have developed unique types of
Infantile fibrosarcoma of the maxillary sinus: significant response.
Enrique Palacios et al.
Ear, nose, & throat journal, 91(3), 98-100 (2012-03-21)
The case of the vexing vesicant.
Seth Eisenberg
ONS connect, 27(10), 19-19 (2012-10-26)
David Drake
Emergency medicine journal : EMJ, 29(9), 777-779 (2012-08-21)
A short cut review was carried out to establish whether intravenous dexrazoxane reduces the risk of tissue necrosis after extravasation of the chemotherapy agent anthracycline. One paper directly addressed the question. The clinical bottom line is that intravenous dexrazoxane appears
James H Doroshow
Current pharmaceutical biotechnology, 13(10), 1949-1956 (2012-02-23)
The cumulative cardiac toxicity of the anthracycline antibiotics and their propensity to produce severe tissue injury following extravasation from a peripheral vein during intravenous administration remain significant problems in clinical oncologic practice. Understanding of the free radical metabolism of these
Volume Transitions of Isolated Cell Nuclei Induced by Rapid Temperature Increase
Chan CJ, et al.
Biophysical Journal, 112(6), 1063-1076 (2017)
J S Whelan et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 26(2), 407-414 (2014-11-26)
Four international study groups undertook a large study in resectable osteosarcoma, which included two randomised controlled trials, to determine the effect on survival of changing post-operative chemotherapy based on histological response. Patients with resectable osteosarcoma aged ≤40 years were treated
Cameron K Tebbi et al.
Pediatric blood & cancer, 59(7), 1259-1265 (2012-08-23)
Hodgkin lymphoma is highly curable but associated with significant late effects. Reduction of total treatment would be anticipated to reduce late effects. This aim of this study was to demonstrate that a reduction in treatment was possible without compromising survival
Cardiotoxicity debated for anthracyclines and trastuzumab in breast cancer.
Vicki Brower
Journal of the National Cancer Institute, 105(12), 835-836 (2013-06-05)
Haruki Hasegawa
Experimental cell research, 379(1), 92-109 (2019-03-10)
Intracellular protein crystallization occurs under various physiological and pathological settings, yet the underlying cellular processes remain enigmatic. After validating individual crystallization events using cellular proteins that readily crystallize in the ER (NEU1), cytosol (crystallin-γD mutant) or nucleus (CLC protein), I
Annie Calvé et al.
Canadian journal of physiology and pharmacology, 90(11), 1527-1534 (2012-11-28)
Childhood cancer survivors can develop significant cardiac dysfunction in adulthood as a consequence of their cancer treatment. Studies have linked heart failure during pregnancy to childhood doxorubicin (DOX) exposure. We hypothesized that DOX injection would reduce cardiac function peripartum and
Minkyoung Kang et al.
Journal of chemotherapy (Florence, Italy), 24(5), 292-296 (2012-11-28)
Anthracyclines play a major role in chemotherapeutic regimens for a variety of pediatric cancers, but produce undesirable dose-related cardiotoxicity. Dexrazoxane reduces early myocardial injury during anthracycline treatment, but data remain insufficient to fully understand its cardioprotective effectiveness in treating pediatric
S M Attia et al.
Cancer chemotherapy and pharmacology, 77(1), 27-33 (2015-12-10)
Despite dexrazoxane's increasing use in mitigating doxorubicin-induced cardiotoxicity, no data are available in the literature on the potential aneugenicity of drug combination. Therefore, detailed evaluation of aneugenic potential of this combination is essential to provide more insights into aneuploidy induction
M Doornaert et al.
Acta chirurgica Belgica, 113(1), 1-7 (2013-04-05)
Extravasation is a devastating complication of intravenous therapy that develops when a drug infiltrates the interstitial tissue surrounding the vein. Due to the uncertain and possibly dramatic outcome, early recognition and adequate treatment with the aid of a standardized protocol
Libuše Zatloukalová et al.
Canadian journal of physiology and pharmacology, 90(4), 473-484 (2012-03-24)
Positive effects of dexrazoxane (DEX) in anthracycline cardiotoxicity have been mostly assumed to be associated with its iron-chelating properties. However, this explanation has been recently questioned. Iron plays also an important role in the catecholamine cardiotoxicity. Hence in this study
Daniel Stromberg et al.
Annals of the New York Academy of Sciences, 1270, 59-65 (2012-10-12)
Neonates and infants undergoing heart surgery with cardioplegic arrest experience both inflammation and myocardial ischemia-reperfusion (IR) injury. These processes provoke myocardial apoptosis and oxygen-free radical formation that result in cardiac injury and dysfunction. Thymosin β4 (Tβ4) is a naturally occurring
Patrizia Fabbi et al.
PloS one, 10(5), e0124643-e0124643 (2015-05-09)
Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by activating type 1 IGF receptor (IGF-1R). Within the myocardium, IGF-1 action is modulated by IGF binding protein-3 (IGFBP-3), which sequesters IGF-1 away from IGF-1R. Since cardiomyocyte apoptosis is implicated in
Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin's disease
Tebbi CK, et al.
Journal of Clinical Oncology, 25(5), 493-500 (2007)
Martin Stěrba et al.
Antioxidants & redox signaling, 18(8), 899-929 (2012-07-17)
Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among the most effective anticancer drugs, but their clinical usefulness is hampered by the risk of cardiotoxicity. The most feared are the chronic forms of cardiotoxicity, characterized by irreversible cardiac damage and congestive heart
Christel Fontaine et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 20(5), 1109-1112 (2012-01-27)
Anthracycline extravasation (ACEV) is a rare but potentially devastating event which can result in severe injuries including ulceration and necrosis, slow-healing lesions, serious joint damage and permanent disfigurement. It can delay further scheduled chemotherapy and affect cancer treatment outcome. Savene®
The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia
Lipshultz SE, et al.
The New England Journal of Medicine, 351(2), 145-153 (2004)
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