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Showing 1-30 of 442 results for "D5025" within Papers
John T Benjamin et al.
The Journal of clinical investigation, 131(1) (2020-10-28)
Emerging evidence indicates that early life events can increase the risk for developing chronic obstructive pulmonary disease (COPD). Using an inducible transgenic mouse model for NF-κB activation in the airway epithelium, we found that a brief period of inflammation during
Liling Wang et al.
Theranostics, 12(17), 7216-7236 (2022-11-29)
Rationale: Recurrent pregnancy loss (RPL) is a distressing disorder that seriously affects the physical and psychological health of women. RPL is also a sentinel risk marker for future obstetric complications and warrants in-depth investigation. Abnormal polarization and functions of decidual
Nikolaj Riis Christensen et al.
iScience, 25(2), 103808-103808 (2022-02-25)
The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein-protein interactions (PPIs) which constitute a functional postsynapse. The PSD protein 95 (PSD-95) interacts with a manifold of proteins, including the C-terminal of transmembrane
Femke Stephan et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(3), 686-693 (2014-02-28)
Removal of dead cells is essential in the maintenance of tissue homeostasis, and efficient removal prevents exposure of intracellular content to the immune system, which could lead to autoimmunity. The plasma protease factor VII-activating protease (FSAP) can release nucleosomes from
Ido Rippin et al.
International journal of molecular sciences, 21(22) (2020-11-22)
The serine/threonine kinase, GSK-3, is a promising drug discovery target for treating multiple pathological disorders. Most GSK-3 inhibitors that were developed function as ATP competitive inhibitors, with typical limitations in specificity, safety and drug-induced resistance. In contrast, substrate competitive inhibitors
Maria V Rogacheva et al.
The Journal of biological chemistry, 289(9), 5664-5673 (2014-01-10)
Crossing over between homologous chromosomes is initiated in meiotic prophase in most sexually reproducing organisms by the appearance of programmed double strand breaks throughout the genome. In Saccharomyces cerevisiae the double-strand breaks are resected to form three prime single-strand tails
Andrew B Stergachis et al.
Science (New York, N.Y.), 342(6164), 1367-1372 (2013-12-18)
Genomes contain both a genetic code specifying amino acids and a regulatory code specifying transcription factor (TF) recognition sequences. We used genomic deoxyribonuclease I footprinting to map nucleotide resolution TF occupancy across the human exome in 81 diverse cell types.
Chengcong Yin et al.
Mucosal immunology, 13(6), 892-907 (2020-07-29)
Acute respiratory distress syndrome (ARDS) is a kind of comprehensive disease with excessive inflammation and high clinical mortality. Multiple immune cells are involved in the ARDS process. Amongst these populations, lung-resident alveolar macrophages (AMs) are known to participate in the
Ariel Poliandri et al.
Molecular and cellular endocrinology, 447, 12-22 (2017-02-25)
GnRH neurons are fundamental for reproduction in all vertebrates, integrating all reproductive inputs. The inaccessibility of human GnRH-neurons has been a major impediment to studying the central control of reproduction and its disorders. Here, we report the efficient generation of
Ilaria Cavallari et al.
Methods in molecular biology (Clifton, N.J.), 1087, 325-337 (2013-10-26)
Like other complex retroviruses such as HIV-1, HTLV-1 encodes several regulatory and auxiliary non-structural proteins from overlapping open reading frames through the generation of alternatively spliced mRNAs. HTLV-1 expression is orchestrated by the Tax and Rex regulatory proteins; Tax drives
Julika Pitsch et al.
Annals of neurology, 89(4), 666-685 (2020-12-29)
Limbic encephalitis (LE) comprises a spectrum of inflammatory changes in affected brain structures including the presence of autoantibodies and lymphoid cells. However, the potential of distinct lymphocyte subsets alone to elicit key clinicopathological sequelae of LE potentially inducing temporal lobe
Gulcan Semra Sahin et al.
Science signaling, 14(683) (2021-05-20)
Developing hippocampal neurons undergo rapid synaptogenesis in response to neurotrophic signals to form and refine circuit connections. The adipokine leptin is a satiety factor with neurotrophic actions, which potentiates both glutamatergic and GABAergic synaptogenesis in the hippocampus during neonatal development.
Q Liang et al.
Clinical and experimental immunology, 203(1), 55-65 (2020-10-06)
Semi-allogeneic embryos are not rejected by the maternal immune system due to maternal-fetal immune tolerance. Progesterone (P) receptor (PR)-expressing γδ T cells are present in healthy pregnant women. In the presence of P, these cells secrete an immunomodulatory protein called
Marta Trüb et al.
Journal for immunotherapy of cancer, 8(2) (2020-07-04)
The costimulatory receptor 4-1BB (CD137, TNFRSF9) plays an important role in sustaining effective T cell immune responses and is investigated as target for cancer therapy. Systemic 4-1BB directed therapies elicit toxicity or low efficacy, which significantly hampered advancement of 4-1BB-based
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation.
Anton Maximov et al.
Journal of neuroscience methods, 161(1), 75-87 (2006-11-23)
Various techniques have been applied for the functional analysis of synaptic transmission in cultured neurons. Here, we describe a method of studying synaptic transmission in neurons cultured at high-density from different brain regions such as the cortex, striatum and spinal
Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation.
Choi, et al.
Nature Communications, 14, 2045-2045 (2023)
Szymon P Kordon et al.
Nature communications, 14(1), 635-635 (2023-02-07)
Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular regions that bind to multiple ligands to regulate key biological functions including neurodevelopment and organogenesis. Modulating a single function of a specific aGPCR isoform while affecting no other function
[NETs in pathogenesis of vasculitis].
Daigo Nakazawa et al.
Nihon Jinzo Gakkai shi, 56(2), 117-123 (2014-04-16)
M Lahn et al.
Oncology, 54(5), 429-437 (1997-09-01)
We compared the cytogenetic pattern of 20 different primary tumor cell cultures (PTCC) of renal cell carcinoma (RCC) to their cytokine secretion and oncogene expression. High secretion of IL-6 (gene locus on chromosome 7p21-p14) was correlated with the gain of
Naveen Sharma et al.
The Journal of experimental medicine, 218(7) (2021-05-12)
Immune receptors expressed on TAMs are intriguing targets for tumor immunotherapy. In this study, we found inhibitory receptor LILRB4 on a variety of intratumoral immune cell types in murine tumor models and human cancers, most prominently on TAMs. LILRB4, known
Jing Wang et al.
Journal of hazardous materials, 373, 504-518 (2019-04-05)
Previous studies have demonstrated that toxins produced by toxic cyanobacterial blooms are hazardous materials. Although microcystin-LR (MC-LR) has been revealed to inflict damage to the brain, the mechanisms underlying its neurotoxicity as a result of chronic exposure to MC-LR are
Olga A Boubriak et al.
Journal of anatomy, 222(3), 341-348 (2013-01-15)
The intervertebral disc is an avascular tissue, maintained by a small population of cells that obtain nutrients mainly by diffusion from capillaries at the disc-vertebral body interface. Loss of this nutrient supply is thought to lead to disc degeneration, but
Nir Bujanover et al.
Stem cell reports, 16(8), 1884-1893 (2021-07-24)
Immune cells are generated from hematopoietic stem cells (HSCs) in the bone marrow (BM). Immune stimulation can rapidly activate HSCs out of their quiescent state to accelerate the generation of immune cells. HSCs' activation follows various viral or bacterial stimuli
António Galvão et al.
Endocrinology, 157(2), 858-871 (2015-12-15)
In the present work, we investigated the role of Nodal, an embryonic morphogen from the TGFβ superfamily in corpus luteum (CL) secretory activity using cells isolated from equine CL as a model. Expression pattern of Nodal and its receptors activin
Adam N R Cartwright et al.
Cancer immunology research, 9(4), 470-485 (2021-01-31)
Tumor-infiltrating myeloid-derived suppressor cells (MDSC) are associated with poor survival outcomes in many human cancers. MDSCs inhibit T cell-mediated tumor immunity in part because they strongly inhibit T-cell function. However, whether MDSCs inhibit early or later steps of T-cell activation
Kana Ohashi et al.
Pflugers Archiv : European journal of physiology, 470(5), 705-716 (2018-03-24)
Oligodendrocytes, which differentiate from oligodendrocyte precursor cells (OPCs), ensheath axons with myelin, play an essential role in rapid conduction of action potentials and metabolically support neurons. Elucidation of the mechanisms underlying the proliferation, migration, differentiation, and survival of OPCs is
Pierre Bost et al.
Cell, 181(7), 1475-1488 (2020-06-02)
Viruses are a constant threat to global health as highlighted by the current COVID-19 pandemic. Currently, lack of data underlying how the human host interacts with viruses, including the SARS-CoV-2 virus, limits effective therapeutic intervention. We introduce Viral-Track, a computational
V S Chouhan et al.
Theriogenology, 84(7), 1185-1196 (2015-08-06)
The purpose of this study was to evaluate the temporal (24, 48, and 72 hours) and dose-dependent (0, 5, 10, and 100 ng/mL of LH, insulin-like growth factor 1 [IGF-1], and EGF) in vitro expression and secretion patterns of vascular
Yuqiu Lu et al.
Methods in molecular biology (Clifton, N.J.), 2377, 333-343 (2021-10-29)
Identification of genes essential for structure, function, and survival of a cell type is critical for understanding of the underlying mechanisms. Unfortunately, there is no efficient way to identify such genes. Studies by single-cell RNA sequencing have shown that gene
Victoria Male et al.
Methods in molecular biology (Clifton, N.J.), 612, 447-463 (2009-12-25)
Natural killer (NK) cells account for 70% of the leukocytes in the mucosal lining of the uterus (the decidua) in the first trimester of pregnancy. They are CD56(superbright) granulated cells expressing a repertoire of Killer-cell Immunoglobulin-like Receptors (KIR) skewed towards
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