Pharma and biopharma manufacturing

Applied Filters:

facet applications:Pharma and biopharma manufacturing

facet content type:Technical Article

Showing 1-30 of 47 results

Bioprocessing And Scale-Up Of Suspension HEK293 Cells For AAV Manufacturing

To address scalability challenges of AAV manufacturing, we developed an HEK293 suspension cell line that can be used across many serotypes. Get the data in this article.

Improving Antibody-drug Conjugate (ADC) Solubility with Hydrophobic Novel Payloads Using the Chito-oligosaccharide ChetoSensar™

See the data on how the chito-oligosaccharide ChetoSensar™ overcomes ADC solubility challenges.

In-Line Real-Time Monitoring of CHO Cell Culture Process Parameters using Raman Spectroscopy

This page explains how to monitor in-line and in real time CHO cell culture process parameters using Raman spectroscopy.

Scalability and Performance of Mobius^® iFlex Bioreactors

This page summarizes several performance attributes and scalability data for Mobius® iFlex Bioreactors, single-use, stirred tank systems designed to support traditional and intensified fed-batch and perfusion cell culture applications.

Improving Efficiency and Control in Biopharma Manufacturing With Process Analytical Technology

Key considerations for process analytical technology (PAT) implementation in biopharma and its role in enabling the facility of the future.

Dry Granulation in Solid Oral Formulation: Advantages of Spray-Dried Mannitol in Roll Compaction

In recent years, mannitol has gained popularity as an excipient in solid dosage formulation due to its beneficial physicochemical properties.

Integrated Glucose Control in CHO Culture via Raman Spectroscopy

Discover opportunities of a Raman PAT platform for feedback control loop in CHO cell culture, enabling stable glucose levels without manual intervention.

Solid Formulation Development Using Melt-based 3D Printing Technologies

3D printing can overcome challenges during formulation development, with a focus on enhancing API bioavailability in solid dispersions. Find out how in this technical article.

Use of PVA to Overcome Challenges in Ophthalmic Formulations

PVA meets all the essential requirements to be used in ophthalmic preparations and offers important benefits compared to HPMC and CMC.

Chromatographic Purification of Plasmid DNA (pDNA) for mRNA, Plasmid-based DNA Vaccines, and Viral Vector Applications

See case study examples of how to optimize chromatographic purification of plasmid DNA for Biopharmaceutical Applications.

Protein Binding Determination Using Supel™ BioSPME C18 Pin Device as Part of the Manual Methodology With and Without Shaking

The application note describes a comparative analysis of plasma protein binding results for free/bound drugs using two different sample extraction steps, with and without agitation.

Improving Fed-batch Yields in Upstream Bioprocessing

Our step-by-step guide to optimizing media and feed combinations for upstream bioprocessing.

Optimizing Upstream Media and Feeds in Bioprocessing

Why optimize your upstream bioprocess media and feed? This article discusses the why and how of optimizing your media and feed to maximize cell viability and productivity.

Chemically Defined Media Supplements Improve Quality and Lower Risk in Upstream Bioprocessing

Chemically defined media supplements offer many benefits including decreased lot-to-lot variation, decreased risks, and improved glycosylation profiles.

What is an Antibody-Drug Conjugate?

What antibody drug conjugates are, how bioconjugates work, design considerations and ADC services for ADC manufacturing, including bioconjugation.

Simplifying Antibody-Drug Conjugate Payload Synthesis Using Payload Intermediates

ADC payload intermediates such as, DOLCore ™, MAYCore ™, and PBDCore ™, simplify payload synthesis for the most commonly used payloads: maytansine, dolastatin, and PBD dimers.

AAV Process Intensification Using High Salt Lysis and Salt Tolerant Endonuclease

This page describes key considerations for cell lysis and how the combination of a high salt concentration and a salt tolerant endonuclease can be used to increase vector titer and infectivity during AAV vector manufacturing.

Enhance Solubility With 3D Printing and Mesoporous Silica

Accelerate formulation of APIs with solubility challenges using additive manufacturing (3D printing) with mesoporous silica. Explore this case study!

Viscosity Reduction in High Concentration TFF

This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.

Tangential Flow Filtration in Downstream Bioprocessing

There are many options for tangential flow filtration (TFF) in downstream bioprocessing from multi-use to single-use TFF or batch TFF and single-pass TFF.

Single-Pass Tangential Flow Filtration Implementation and Scaling

Get practical guidance on using single-pass tangential flow filtration in your downstream process and scaling between capsules and cassettes.

Ultrafiltration/Diafiltration (UF/DF) in Plasmid DNA Manufacturing

How are ultrafiltration and diafiltration used in plasmid DNA manufacturing and how should you optimize this process? Learn more in our technical article and download our free eBook.

Direct upstream monitoring with Raman ready-to-use models

Streamline upstream process monitoring with embedded Raman ready-to-use models for easy implementation and improved process understanding

Upstream Bioprocessing Feed Strategies and Scalability: A Case Study with Cellvento^® ModiFeed Prime COMP

This case study walks through optimizing feed and media for upstream bioprocessing and how it translates to large-scale bioreactors.

An Optimized Protocol for Peptide Mapping of Therapeutic Monoclonal Antibodies with Minimum Deamidation and Oxidation Artifacts

An optimized peptide mapping protocol using NISTmAb as a model monoclonal antibody, shorter incubation times, and improved digestion buffer to demonstrate minimal artificial asparagine deamidation and methionine oxidation.

Scalability Challenges of Viral Vector Manufacturing

Scaling up viral vector production using adherent cell culture systems is challenging. Learn how suspension cell culture systems benefit large-scale bioprocessing.

Bioreactor Process Development and Scale-Up for Transient Transfection-Based Lentivirus Manufacturing in Suspension Cell Culture

A step-by-step overview of suspension-based, transient transfection bioreactor process development and scaleup of lentivirus production.

Impact of DMSO And Freezing Technique in Developing a High Cell Density Cryopreservation Process for Upstream Bioprocessing

Understand how considerations such as DMSO concentrations and freezing techniques are key in the successful implementation of high cell density cryopreservation (HCDC).

Seed Train Intensification Using High Cell Density Cryopreservation

High cell density cryopreservation (HCDC) is a closed processing alternative to the traditional seed train expansion process. Learn more about the benefits of HCDC.

Lentivirus Platform: Optimizing Performance for De-Risked Production

Learn how the VirusExpress® lentivirus platform utilizes DoE experiments and supplementary studies to optimize workflows, enhance yield, and ensure quality in cell and gene therapies.

Page 1 of 2