Reaction design and optimization

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Trichloroacetimidates are also commonly employed as alcohol alkylation reagents, particularly when existing functionality is not acid sensitive.

Tetrakis(dimethylamino)ethylene (TDAE)

In 2001, Professor William Dolbier, Jr., at the University of Florida reported1 an approach to nucleophilic trifluoromethylation based on the generation of a trifluoromethyl anion using CF3I in the presence of a powerful twoelectron reductant, tetrakis(dimethylamino)ethylene (TDAE)

Organic Azides and Azide Sources

Since the preparation of the first organic azide, phenyl azide, by Peter Griess in 1864 this energy-rich and versatile class of compounds has enjoyed considerable interest.

Sodium Triacetoxyborohydride

Sodium triacetoxyborohydride

Lithium Aminoborohydride (LAB) Reagents

Lithium aminoborohydride (LAB) reagents are a new class of powerful and selective reagents developed in the laboratory of Professor Bakthan Singaram at the University of California, Santa Cruz.

BINAP/SEGPHOS® Ligands and Complexes

We present an article concerning BINAP/SEGPHOS® Ligands and Complexes.

Chiral Phosphoric Acids: Versatile Organocatalysts with Expanding Applications

TRIP and TiPSY Chiral Phosphoric Acid Catalysts

KitAlysis™ High-Throughput Screening Platform

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

Glycol Ethers Properties & Examples, Organic Solvents

Glycol ethers, with both an ether and alcohol functional group in the same molecule, are one of the most versatile classes of organic solvents.

Chiral Amines in Asymmetric Synthesis

Chiral amines have found widespread application in asymmetric synthesis serving, for instance, as chiral bases in enantioselective deprotonation reactions or being valuable substances for resolving racemic mixtures of acids.

ChiPros Chiral Alcohols

Chiral alcohols form a versatile class of chiral synthons, since they can be incorporated into the API structures directly as esters or ethers.

BINOL and Derivatives

We present an article concerning BINOL and Derivatives.

CBS Catalysts

we are pleased to offer both enatiomers of 2-methyl-CBS-oxazaborolidine as a dry reagent, in addition to our current offerings as a 1M solution in toluene.

SyTracks Carbon Monoxide Generator FAQs

What is COgen? What is COware? What is the SyTracks COgenerator system? And more questions answered.

Greener Methods: Catalytic Amide Bond Formation

We are proud to offer a number of products used in catalytic amidation technology.

Spirocyclic Building Blocks for Scaffold Assembly

Spirocyclic modules containing four-membered rings are currently of growing interest to discovery chemists.

Peroxide Forming Solvents

Information on laboratory solvents that can undergo autoxidation under normal storage conditions to form unstable and potentially dangerous peroxide by-products.

Verkade's Bases

Verkade's bases are used in a variety of organic reactions, such as alkylations, dehydrohalogenations, acylations, and condensation and organometallic reactions for carbon-carbon bond formation.

Phosphazene Bases

Phosphazene base reagents are available as monomeric (P1 and BEMP), dimeric (P2), and tetrameric (P4) bases with different side chains to control their sterical hindrance.

Traditional Strong and Hindered Bases

The basicity strength for some of our traditional bases, including DBU, DBN, and n-BuL are listed for easy comparison.

KitAlysis™ Photocatalysis Reaction Screening Kit

PhotoKitAlysis Reaction Kit aids in cross-coupling reactions, offering pre-weighed components for optimization.

Chiral Diene Ligands for Asymmetric Transformations

Chiral diene ligands enable asymmetric transformations, constructing enantioenriched compounds from achiral substrates efficiently.

Q-Phos

Q-Phos ligand by Professor Hartwig enables diverse C-N, C-O, and C-C bondforming reactions in coupling reactions.

Imidazolium-Derived Reagents

N-Acylimidazoles and carbonylimidazoles are reactive intermediates used for amino compound acylation, surpassing DCC as coupling reagents.

Molecular Sieves

Molecular sieves selectively adsorb molecules, crucial for various industrial processes.

Functionalized Alkynes

Alkynes' versatility enables reactions like addition, metathesis, hydroboration, cleavage, coupling, and cycloadditions in synthetic chemistry.

Maruoka Catalysts

Maruoka catalysts enable enantioselective preparation of α-amino acids from glycine derivatives via asymmetric phase transfer catalysis.

Chiral Diols

TADDOLs demonstrate versatility in metal-catalyzed asymmetric reactions and as Brønsted acid organocatalysts in hetero-Diels–Alder reactions.

Aldehydes as Building Blocks

Synthesis of selective aldosterone synthase inhibitors using Wittig reaction with heterocyclic aldehydes described in study by Hartmann et al.

Aerobic Alcohol Oxidation Solutions

Alcohol oxidation yields aldehydes and ketones, crucial intermediates in organic synthesis.

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