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Showing 1-30 of 5495 results for "L011800" within Papers
Ji Liu et al.
Journal of proteomics, 126, 68-81 (2015-06-07)
Male sterility is a common phenomenon in flowering plants, and it has been successfully developed in several crops by taking advantage of heterosis. Cotton (Gossypium hirsutum L.) is an important economic crop, used mainly for the production of textile fiber.
Joao N Dos Santos Pereira et al.
The AAPS journal, 16(6), 1247-1258 (2014-08-27)
Variations in influx transport at the blood-brain barrier might affect the concentration of psychotropic drugs at their site of action and as a consequence might alter therapy response. Furthermore, influx transporters in organs such as the gut, liver and kidney
Lin Zhu et al.
Food chemistry, 194, 1320-1328 (2015-10-17)
Nearly 50% of naturally-occurring pyrrolizidine alkaloids (PAs) are hepatotoxic, and the majority of hepatotoxic PAs are retronecine-type PAs (RET-PAs). However, quantitative measurement of PAs in herbs/foodstuffs is often difficult because most of reference PAs are unavailable. In this study, a
Simona Summa et al.
Food chemistry, 187, 477-484 (2015-05-16)
A simple, sensitive and selective multiresidue high-performance liquid chromatography with diode array detection method for determination of 13 sulphonamides in eggs was developed and validated. Sample extraction and clean-up conditions were carefully studied and factors as gradient elution and column
Ting Yang et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 283-289 (2014-06-28)
P-glycoprotein (P-gp) can efflux drugs from cancer cells, and its overexpression is commonly associated with multi-drug resistance (MDR). Thus, the accurate quantification of P-gp would help predict the response to chemotherapy and for prognosis of breast cancer patients. An advanced
Yuanyuan Chen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 1-5 (2015-02-04)
Solasonine, a known glycoalkaloid, is a potential anti-cancer agent. In this work, a simple, sensitive and fast ultra performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitative determination of solasonine in rat plasma.
Samantha Jardon-Xicotencatl et al.
Toxins, 7(10), 4294-4314 (2015-10-30)
Aflatoxins, a group of extremely toxic mycotoxins produced by Aspergillus flavus, A. parasiticus and A. nomius, can occur as natural contaminants of certain agricultural commodities, particularly maize. These toxins have been shown to be hepatotoxic, carcinogenic, mutagenic and cause severe
Heng Zhang et al.
European journal of medicinal chemistry, 89, 524-539 (2014-12-03)
We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity
Maaike Welling et al.
EMBO reports, 16(7), 791-802 (2015-06-17)
Embryonic stem cell (ESC) cultures display a heterogeneous gene expression profile, ranging from a pristine naïve pluripotent state to a primed epiblast state. Addition of inhibitors of GSK3β and MEK (so-called 2i conditions) pushes ESC cultures toward a more homogeneous
Brian Chapron et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 18(1), 101-111 (2015-04-17)
Telaprevir inhibits CYP3A resulting in drug-drug interactions (DDI) of unprecedented magnitude. We investigated the mechanisms by which telaprevir inhibits the oxidation of midazolam and tacrolimus in human liver microsomes (HLM). We performed a static mechanistic DDI prediction to evaluate whether
Free fatty acid particles in protein formulations, part 2: contribution of polysorbate raw material.
Christine C Siska et al.
Journal of pharmaceutical sciences, 104(2), 447-456 (2014-09-10)
Polysorbate 20 (PS20) is a nonionic surfactant frequently used to stabilize protein biopharmaceuticals. During the development of mAb formulations containing PS20, small clouds of particles were observed in solutions stored in vials. The degree of particle formation was dependent on
Kiyoko Nagahama et al.
Bioscience, biotechnology, and biochemistry, 79(8), 1327-1336 (2015-04-08)
Natural killer (NK) cells play a key role in innate immune defense against infectious disease and cancer. A reduction of NK activity is likely to be associated with increased risk of these types of disease. In this study, we investigate
Ki-Suk Kim et al.
The American journal of Chinese medicine, 43(3), 425-441 (2015-05-15)
As a treatment for allergic asthma, inhaled treatments such as bronchodilators that contain β2-agonists have an immediate effect, which attenuates airway obstructions and decreases airway hypersensitivity. However, bronchodilators only perform on a one off basis, but not consistently. Asthma is
Yadollah Yamini et al.
Journal of separation science, 37(17), 2364-2371 (2014-06-26)
A new type of liquid-phase microextraction based on two immiscible organic solvents was optimized and validated for the quantification of lidocaine, ketamine, and cocaine in human urine samples. A hollow-fiber based microextraction technique followed by gas chromatography coupled with mass
Nicholas A Williams et al.
Journal of pharmaceutical sciences, 104(7), 2233-2240 (2015-05-20)
Intravesical oxybutynin is highly effective in the treatment of overactive bladder. Traditionally the mechanism of action was explained by antagonism of muscarinic receptors located in the detrusor, however evidence now suggests antimuscarinics may elicit their effect by modifying afferent pathways
Xiao Wei et al.
Analytica chimica acta, 870, 83-91 (2015-03-31)
This paper reports a facile and general method for preparing an imprinted polymer thin shell with Mn-doped ZnS quantum dots (QDs) at the surface of silica nanoparticles by stepwise precipitation polymerization to form the highly-controllable core-shell nanoparticles (MIPs@SiO2-ZnS:Mn QDs) and
K F Ho et al.
Environmental pollution (Barking, Essex : 1987), 197, 316-324 (2014-12-01)
A sampling campaign was carried out at nine Chinese cities in 2010/2011. Fifteen monocarbonyls (C# = 1-9) were quantified. Temperature is the rate-determining factor of the summertime carbonyl levels. The carbonyl emissions in winter are mainly driven by the primary
Keun-Hong Kim et al.
Acta biochimica et biophysica Sinica, 46(6), 441-449 (2014-04-20)
Lung cancer is the most common cancer and the leading cause of cancer-related deaths. Panax ginseng has long been used to treat cancer and other diseases worldwide. Most of the pharmacological actions of ginseng are attributed to a variety of
Berta Cillero-Pastor et al.
Analytical and bioanalytical chemistry, 407(8), 2213-2222 (2014-12-17)
The remodeling of the synovial membrane, which normally lubricates the joints by producing synovial fluid, is one of the most characteristic events in the pathology of osteoarthritis (OA). The heterogeneity and spatial distribution of proteins in the synovial membrane are
Shun Tang et al.
Water research, 73, 342-352 (2015-02-24)
The monochloroacetic, dichloroacetic and trichloroacetic acid (MCAA, DCAA and TCAA) removed by metallic iron under controlled dissolved oxygen conditions (0, 0.75, 1.52, 2.59, 3.47 or 7.09 mg/L DO) was investigated in well-mixed batch systems. The removal of CAAs increased first
Katarina Hostanska et al.
The Journal of pharmacy and pharmacology, 66(11), 1606-1614 (2014-09-02)
Extracts of the tubers of Harpagophytum procumbens (devil's claw, DC) inhibit different proinflammatory mediators important in the pathophysiology of osteoarthritis. Many plant-derived preparations interfere with cytochrome P450 liver enzymes, which influence their different biological activities. Therefore, the present study was
Daniel G Beach et al.
Analytical and bioanalytical chemistry, 407(28), 8397-8409 (2015-09-24)
The neurotoxin β-N-methylamino-L-alanine (BMAA) has been reported in cyanobacteria and shellfish, raising concerns about widespread human exposure. However, inconsistent results for BMAA analysis have led to controversy. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the most appropriate method for analysis of
Ahmed Alsaqr et al.
AAPS PharmSciTech, 16(4), 963-972 (2015-01-23)
Transdermal delivery of therapeutic amounts of vitamin D3 is proposed to overcome its variable oral bioavailability, especially for people who suffer from fat malabsorption. The main challenge for this delivery route is to overcome the barrier properties of skin, especially
Ayorinde Adehin et al.
Drug metabolism and personalized therapy, 30(3), 203-210 (2015-06-23)
CYP1A2 and CYP2A6 are polymorphic enzymes that metabolise several compounds of clinical importance. This study investigated the prevalent phenotypes of these enzymes and the influence of age and sex on enzyme activity in a Nigerian population. Caffeine (110 mg) was
Adrian Marley et al.
Journal of pharmaceutical and biomedical analysis, 102, 261-266 (2014-12-03)
A new stability indicating reversed phase high performance liquid chromatography (RP-HPLC) method was developed and validated under current International Conference of Harmonisation (ICH) guidance for the determination of prednisolone acetate (PAC) and impurities in an ophthalmic suspension. The developed method
M Lloberas et al.
New Zealand veterinary journal, 63(4), 227-234 (2015-02-18)
To compare the pharmacokinetics, distribution and efficacy (pharmacodynamic response) of intraruminal ivermectin (IVM) and moxidectin (MXD) administered at 0.2 and 0.4 mg/kg to naturally nematode-infected lambs, and to determine the ex vivo accumulation of these anthelmintics by Haemonchus contortus. Romney
Morten S Opstrup et al.
Contact dermatitis, 72(1), 55-58 (2014-09-12)
Chlorhexidine may cause type I and type IV allergy. Some chlorhexidine-allergic individuals have been exposed in the healthcare setting as patients or healthcare workers, but for others the source of sensitization is unknown. Chlorhexidine may be used as a preservative
François Versace et al.
Bioanalysis, 6(15), 2043-2055 (2014-10-18)
Direct-infusion ESI-MS/MS is a powerful approach for the identification of substances in complex mixtures. The aim of this work was to investigate its applicability to the toxicological screening of blood samples. A simple protein precipitation was used, followed by a
Yan Liu et al.
Microbial cell factories, 14, 50-50 (2015-04-18)
The filamentous fungus Acremonium chrysogenum is an important industrial fungus and is used in the production of the β-lactam antibiotic cephalosporin C. Little is known regarding the molecular and biological mechanisms of how this industrial strain was improved by mutagenesis
Antonina Gucciardi et al.
Biomedical chromatography : BMC, 28(8), 1131-1139 (2014-01-23)
Lysosomal storage disorders comprise a group of rare genetic diseases in which a deficit of specific hydrolases leads to the storage of undegraded substrates in lysosomes. Impaired enzyme activities can be assessed by MS/MS quantification of the reaction products obtained
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