Merck
CN
Search Within

PHR1015

Applied Filters:
Keyword:'PHR1015'
Showing 1-30 of 44 results for "PHR1015" within Papers
Takashi Koyanagi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(10), 893-901 (2014-03-22)
1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprotein bound) and ofloxacin (renally eliminated) were evaluated in
Andrée E Gravel et al.
Biochimica et biophysica acta, 1828(6), 1494-1502 (2013-03-12)
The human ether-a-go-go-related gene (hERG) voltage-gated K(+) channels are located in heart cell membranes and hold a unique selectivity filter (SF) amino acid sequence (SVGFG) as compared to other K(+) channels (TVGYG). The hERG provokes the acquired long QT syndrome
Andreas Papassotiropoulos et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(46), E4369-E4374 (2013-10-23)
In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits, including neuropsychiatric disorders. It is not clear, however, to what extent this knowledge can be used as a starting point
Akira Nakagawachi et al.
Masui. The Japanese journal of anesthesiology, 61(9), 988-992 (2012-09-28)
Laparoscopic percutaneous extraperitoneal closure (LPEC), introduced as an alternative to a conventional open inguinal hernia repair in children, has shown a higher incidence of postoperative vomiting (POV). The aim of this study was to examine whether a prophylactic use of
What is your diagnosis? Intracranial parasitic migration.
Allison B Ward et al.
Journal of the American Veterinary Medical Association, 241(6), 693-695 (2012-09-06)
Xintao Wang et al.
Biomedical chromatography : BMC, 27(3), 371-376 (2012-08-16)
A sensitive, rapid and selective ultra-performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method was developed for the determination and pharmacokinetic study of domperidone in human plasma. Diphenhydramine was used as the internal standard. Plasma sample pretreatment involved a one-step liquid-liquid extraction
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Chang-Ik Choi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 909, 65-69 (2012-11-17)
Tamsulosin, a selective α₁-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH). We developed and validated a rapid, sensitive, and simplified liquid chromatography analytical method utilizing tandem mass spectrometry (LC-MS/MS) for the determination of tamsulosin in human
J Rojas et al.
Die Pharmazie, 67(7), 595-597 (2012-08-15)
Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug
Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
Martinez-Algaba C, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(2), 312-321 (2006)
Abbas Ahmadi et al.
Mini reviews in medicinal chemistry, 12(12), 1282-1292 (2012-08-11)
In addition to their antihistamine effects, H1-receptor antagonists possess pharmacological properties that are not uniformly distributed among this class of drugs, such as anti-inflammatory, anti-allergic and antiplatelet activities. In this paper, Cyclizine (1-benzhydryl-4-methyl-piperazine, I), bromodiphenhydramine (2-[(4-bromophenyl)-phenylmethoxy]-N, N-dimethylethanamine, II) and some
Mohan Punja et al.
The American journal of emergency medicine, 31(10), 1536-1536 (2013-08-13)
Intravenous lipid rescue therapy (LRT) may be implemented to attenuate drug toxicity. Little is known about LRT interference with laboratory tests in overdose settings. A 54-year-old man with a history of depression consumed unknown amounts of diphenhydramine, amitriptyline, and acetaminophen
Don W Coulter et al.
Anti-cancer drugs, 24(4), 415-421 (2013-01-19)
A pediatric study has established a maximum tolerated dose (MTD) for temsirolimus (Tem) of more than 150 mg/m intravenously/week. A phase I trial was conducted to establish the MTD for Tem in combination with valproic acid (VPA) in children and
Jeffery R Meinertz et al.
Bulletin of environmental contamination and toxicology, 89(5), 970-974 (2012-09-08)
Freshwater mussel populations are declining in North America. Potential anthropogenic stressors may be contributing to the declines and may include the continual presence of pharmaceutical compounds in waterways. Diphenhydramine hydrochloride (DH) is an over-the-counter antihistamine marketed under several name brand
Benjamin W Friedman et al.
Annals of emergency medicine, 62(4), 311-318 (2013-04-10)
We compare metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, with ketorolac 30 mg intravenously in adults with tension-type headache and all nonmigraine, noncluster recurrent headaches. In this emergency department (ED)-based randomized, double-blind study, we enrolled adults with
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5
Maryam Karimi Khaledi et al.
International journal of clinical pharmacy, 34(6), 822-824 (2012-08-10)
The objective of this case report is to report the development of tardive dyskinesia in an African-American adolescent male after short-term treatment with metoclopramide 10 mg orally three times daily secondary to delayed gastric emptying. The patient developed symptoms of
Baohong Li et al.
Journal of pharmaceutical and biomedical analysis, 76, 192-199 (2013-01-26)
A simple, sensitive and specific method was developed for simultaneous determination of stachydrine and leonurine in rat plasma using diphenhydramine as an internal standard (IS). The separation was performed on an Agilent ZORBAX Eclipse XDB-C(18) column (150mm×4.6mm, i.d., 5μm) at
Determination of antibacterial quaternary ammonium compounds in lozenges by capillary electrophoresis
Taylor B R, et al.
Journal of Chromatography A, 798(1-2), 335-343 (1998)
Quantitative analysis of liquid formulations using FT-Raman spectroscopy and HPLC: The case of diphenhydramine hydrochloride in [TM="Benadryl"]
Orkoula MG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(4), 1406-1411 (2006)
Arvind Rengarajan et al.
Clinical toxicology (Philadelphia, Pa.), 51(6), 493-496 (2013-05-24)
Previous reports describe false-positive urine immunoassay screens for phencyclidine (PCP) associated with use of tramadol, dextromethorphan, or diphenhydramine. The likelihood of these false positives is unknown. We sought to find the relative frequency of false-positive PCP screens associated with these
Olabisi Oduwole et al.
The Cochrane database of systematic reviews, 12(12), CD007094-CD007094 (2014-12-24)
Cough causes concern for parents and is a major cause of outpatient visits. It can impact on quality of life, cause anxiety and affect sleep in parents and children. Several remedies, including honey, have been used to alleviate cough symptoms.
Suzanne Doyon et al.
Clinical toxicology (Philadelphia, Pa.), 51(10), 941-948 (2013-10-18)
Deaths from overdose of acetaminophen (APAP) combination medications are reported, yet the individual ingredients are not well examined as individual putative causes of death. To examine the individual contribution of APAP or other ingredient(s) to fatalities resulting from ingestion of
Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography: Stress test for stability evaluation
Barbas C, et al.
Journal of Chromatography A, 870(1), 97-103 (2000)
Makiko Kido-Nakahara et al.
The Journal of clinical investigation, 124(6), 2683-2695 (2014-05-09)
In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein-coupled receptor endothelin A receptor (ETAR). Here, we have
Mohammed Maniruzzaman et al.
International journal of pharmaceutics, 443(1-2), 199-208 (2012-12-25)
The purpose of the study was to investigate and identify the interactions within solid dispersions of cationic drugs and anionic polymers processed by hot-melt extrusion (HME) technique. Propranolol HCl (PRP) and diphenhydramine HCl (DPD) were used as model cationic active
Suddent onset: be prepared to treat anaphylactic incidents before it's too late.
Rick Rod
JEMS : a journal of emergency medical services, 37(8), 60-64 (2012-11-30)
On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
Adamo A, et al.
Science, 352(6281), 61-67 (2016)
Marc Marino et al.
Journal of neuroscience methods, 211(1), 1-10 (2012-09-14)
Pruritus, the sensation of itch, which evokes reflex scratching behavior, has a diverse etiology. Because of its clinical significance, mechanisms of pruriception are an important topic. In the present work we describe and validate a paw motion detector (PMD) system.
V B Shevchenko et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 84(4), 74-78 (2012-09-06)
The fluorescence spectra of the porous silicon modified by water solutions of biologically active materials and materials of biological origin are recorded as well as the fluorescence spectra of the porous silicon modified by lecithin monolayers grown on the surface
Page 1 of 2