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Showing 1-30 of 3291 results for "PHR1372" within Papers
Lijun Yue et al.
Chemical research in toxicology, 28(3), 532-540 (2015-02-05)
Sulfur mustard (SM) is a highly reactive alkylation vesicant and cytotoxic agent that has been recognized as an animal and human carcinogen. Although the exact mechanism of toxicology is vague, DNA alkylation seems to be responsible for the triggering of
Konrad Gabrusiewicz et al.
Oncotarget, 5(8), 2208-2220 (2014-05-09)
The addition of anti-angiogenic therapy to the few treatments available to patients with malignant gliomas was based on the fact that these tumors are highly vascularized and on encouraging results from preclinical and clinical studies. However, tumors that initially respond
Golo M J Meyer et al.
Analytical and bioanalytical chemistry, 407(3), 761-778 (2014-09-23)
Mesembrine and mesembrenone are the main alkaloids of Sceletium tortuosum, a plant species that was used for sedation and analgesia by the KhoiSan, previously known as Hottentots, a tribe in South Africa. After fermentation, the obtained preparation called "Kanna" or
Zhifeng Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 45-52 (2015-03-10)
An ultra performance liquid chromatography (UHPLC) coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Q-TOF-MS/MS) was used in the structural determination of natural compounds in Gastrodia elata. A total of 64 compounds were identified or tentatively characterized. The strategy used
Barbara Gandolfi et al.
PloS one, 9(10), e109926-e109926 (2014-10-31)
Myotonia congenita (MC) is a skeletal muscle channelopathy characterized by inability of the muscle to relax following voluntary contraction. Worldwide population prevalence in humans is 1:100,000. Studies in mice, dogs, humans and goats confirmed myotonia associated with functional defects in
Rosa María González Paredes et al.
Journal of chromatography. A, 1359, 52-59 (2014-08-13)
A method based on the coupling of in situ extraction and derivatization of chlorophenols (CPs) (2-chlorophenol, 4-chloro-3-methylphenol, 2,4-dichlorophenol, and 2,4,6-trichlorophenol) from soils, accomplishing their preconcentration by means of automated microextraction by packed sorbent (MEPS), is proposed. After extraction and acylation
John G Swales et al.
Analytical chemistry, 86(16), 8473-8480 (2014-08-02)
Cassette dosing of compounds for preclinical drug plasma pharmacokinetic analysis has been shown to be a powerful strategy within the pharmaceutical industry for increasing throughput while decreasing the number of animals used. Presented here for the first time is data
Sindhuri Maddineni et al.
AAPS PharmSciTech, 16(2), 444-454 (2014-11-02)
The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64). Nifedipine was used as a model drug in all of the
Venkata V V R Marada et al.
Pharmacological research, 91, 78-87 (2014-12-08)
The ability of an antineoplastic drug to exert its cytostatic effect depends largely on the balance between its uptake into and extrusion from the cancer cells. ATP driven efflux transporter proteins drive the export of antineoplastic drugs and play a
Dulat Azhibek et al.
Nucleic acids research, 42(15), 9531-9542 (2014-08-02)
Telomerase is a key participant in the telomere length maintaining system in eukaryotic cells. Telomerase RNA and protein reverse transcriptase subunits are essential for the appearance of active telomerase in vitro. Telomerase is active in many cancer types and is
Ryan Sestric et al.
Bioresource technology, 164, 41-46 (2014-05-20)
Growth and TAG production by Yarrowia lipolytica were compared for cells cultured in nitrogen-complete medium containing waste glycerol derived from biodiesel production, as well as pure glycerol, dextrose, or canola oil as the carbon sources. Growth and TAG production were
Edward C Bell et al.
Journal of chromatographic science, 52(9), 1065-1070 (2013-10-31)
A rapid, selective and sensitive ultra-performance liquid chromatography method has been developed for the detection and quantification of tocopherols and retinol in human plasma. Alpha-tocopherol, gamma-tocopherol and retinol are assayed using fluorescence detection. Excitation/emission wavelengths are 295/330 nm and 325/470
Dong-Xia Zhao et al.
Journal of separation science, 38(4), 571-575 (2014-12-11)
We established a qualitative method to analyze the main chemical compositions of the root of Aster tataricus. Most of the peaks were separated on a C(18) column packed with 5.0 μm particles, and 28 compounds were identified, including 11 chlorogenic
Swati Singh et al.
Applied and environmental microbiology, 81(2), 754-764 (2014-11-16)
Xenorhabdus nematophila engages in a mutualistic partnership with the nematode Steinernema carpocapsae, which invades insects, migrates through the gut, and penetrates into the hemocoel (body cavity). We showed previously that during invasion of Manduca sexta, the gut microbe Staphylococcus saprophyticus
Sabine Navis et al.
Aquatic toxicology (Amsterdam, Netherlands), 159, 176-183 (2014-12-30)
Although Daphnia magna is a key species in many lentic freshwater ecosystems and is commonly used as model organism in ecology and ecotoxicology, very little is known about the effects of chemicals on their dormant life stages. Dormant eggs (ephippia)
Verena Wahl et al.
International journal of pharmaceutics, 484(1-2), 95-102 (2015-02-24)
The purpose of this work was to investigate the influence of water content on the secondary structure of a freeze-dried protein (fibrinogen) after a storage period of two weeks. To that end, attenuated reflectance Fourier transformed infrared (ATR-FTIR) and Raman
Xiaochun Guo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 54-61 (2014-06-16)
The roles of glutathione (GSH) and cysteine (Cys) in the detoxification of Microcystin-LR (MC-LR) have recently become a popular area of research. However, lacking analysis methods for MC-LR-GSH and MC-LR-Cys (two main GSH pathway metabolites) in mammals, elucidation of the
Ganesh S Moorthy et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 30-34 (2014-09-30)
We describe a selective and highly sensitive high-performance liquid chromatography-electrospray ionization-collision induced dissociation-tandem mass spectrometry (HPLC-ESI-CID-MS/MS) assay for the pan-antiapoptotic Bcl-2 family inhibitor, obatoclax, in human plasma. Fifty μL plasma specimens were prepared by addition of extraction solution consisting of
Wan Cao et al.
Journal of chromatography. A, 1390, 13-21 (2015-03-10)
This report describes the use of trace-chitosan-wrapped multi-walled carbon nanotubes (CS-MWCNTs) as a sorbent material in dispersive micro solid-phase extraction (DMSPE), which was combined with ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry to analyze phenolic compounds in
Leslie A Mitchell et al.
The American journal of pathology, 185(2), 372-386 (2014-12-02)
Epithelial barrier function is maintained by tight junction proteins that control paracellular fluid flux. Among these proteins is junctional adhesion molecule A (JAM-A), an Ig fold transmembrane protein. To assess JAM-A function in the lung, we depleted JAM-A in primary
Lisa M Parsons et al.
PloS one, 9(10), e107250-e107250 (2014-10-09)
Caenorabditis elegans bus-4 glycosyltransferase mutants are resistant to infection by Microbacterium nematophilum, Yersinia pestis and Yersinia pseudotuberculosis and have altered susceptibility to two Leucobacter species Verde1 and Verde2. Our objective in this study was to define the glycosylation changes leading
Nicholas J Lodge et al.
Nuclear medicine and biology, 41(6), 524-535 (2014-05-06)
A radioligand for measuring the density of corticotropin-releasing factor subtype-1 receptors (CRF1 receptors) in living animal and human brain with positron emission tomography (PET) would be a useful tool for neuropsychiatric investigations and the development of drugs intended to interact
Wenkui Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 117-124 (2015-02-04)
A high-performance liquid chromatography-tandem mass spectrometric (LC-MS/MS) method has been developed and validated for the quantitative analysis of loratadine, an H1 histamine antagonist, in human dried blood spot (DBS) samples following a single self-administered 10 or 20mg oral dose. The
Árpád Könczöl et al.
Journal of ethnopharmacology, 155(1), 776-784 (2014-06-20)
Oxybaphus nyctagineus (Michx.) Sweet has traditionally been used by several Native American tribes predominantly as a topical anti-inflammatory and analgesic agent. To evaluate the antioxidant, analgesic and anti-inflammatory activity of the extracts prepared from the aerial parts of Oxybaphus nyctagineus
Vera Hillewaert et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 981-982, 40-47 (2015-01-21)
Tapentadol is a novel, centrally acting analgesic with 2 mechanisms of action, MOR agonism and noradrenaline (NA) reuptake inhibition in a single molecule. It is the first member of a new therapeutic class, MOR-NRI. A high throughput liquid chromatography-tandem mass
Qingmeng Zhang et al.
Disease markers, 2015, 684794-684794 (2015-04-11)
Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic
Benjamin W Lindsey et al.
The European journal of neuroscience, 40(11), 3591-3607 (2014-09-19)
Teleost fishes retain populations of adult stem/progenitor cells within multiple primary sensory processing structures of the mature brain. Though it has commonly been thought that their ability to give rise to adult-born neurons is mainly associated with continuous growth throughout
Sara Boenzi et al.
Clinica chimica acta; international journal of clinical chemistry, 437, 93-100 (2014-07-20)
Two oxysterols, cholestan-3β,5α,6β-triol (C-triol) and 7-ketocholesterol (7-KC), have been recently proposed as diagnostic markers of Niemann-Pick type C (NP-C) disease, representing a potential alternative diagnostic tool to the more invasive and time consuming filipin test in cultured fibroblasts. Usually, the
Santo Scalia et al.
Acta pharmaceutica (Zagreb, Croatia), 64(2), 257-265 (2014-06-11)
The aim of the study was to examine the effect of topical vehicles on the in vivo human stratum corneum penetration of the antioxidant and skin photoprotective agent (-)-epigallocatechin-3-gallate (EGCG). Model oil-in-water (o/w) emulsion and gel formulations containing 1 %
Meitong Zang et al.
Malaria journal, 13, 478-478 (2014-12-06)
Dihydroartemisinin (DHA) is a component of artemisinin-based combination therapy (ACT), which is widely recommended for treatment of uncomplicated falciparum malaria. DHA is also the main metabolite of artemether and artesunate, both of which are used in ACT. Due to auto-induction
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