PHR1446

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Showing 1-11 of 11 results for "PHR1446" within Papers

Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.

K E Kristensen et al.

Clinical pharmacology and therapeutics, 96(6), 713-722 (2014-09-16)

Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) are also metabolized by this enzyme. We examined the effects of ACEIs on clopidogrel

Genotype-based dosage of acenocoumarol in highly-sensitive geriatric patients.

Roberto Lozano et al.

International journal of clinical pharmacology and therapeutics, 53(3), 206-210 (2015-02-12)

Our aim was to determinate the acenocoumarol dose requirement in highly sensitive geriatric patients, based on a minimum of genotype (VKORC1 and CYP2C9) data. We used a Gaussian kernel density estimation test to identify patients highly sensitive to the drug

Comparing individual angiotensin-converting enzyme inhibitors with losartan in the risk of hospitalization for pneumonia and related mortality: a nationwide cohort study.

Chia-Hsuin Chang et al.

Journal of hypertension, 33(3), 634-642 (2014-12-06)

Angiotensin-converting enzyme (ACE) inhibitors might decrease the risk of pneumonia, but head-to-head comparisons with angiotensin receptor blockers (ARBs) were seldom made. The objective of this study was to evaluate incidence of pneumonia and mortality for different ACE inhibitors as compared

Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Haruka Nishimuta et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1522-1531 (2014-07-06)

Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydrolyzed by

Effects of RAS inhibitors on diabetic retinopathy: a systematic review and meta-analysis.

Bin Wang et al.

The lancet. Diabetes & endocrinology, 3(4), 263-274 (2015-02-11)

Results of several studies have shown a possible beneficial effect of renin-angiotensin system (RAS) inhibitors on diabetic retinopathy, but the findings were contradictory. We did a systematic review and meta-analysis to assess the effect of RAS inhibitors on diabetic retinopathy.

A validated HPLC method for analysis of atorvastatin calcium, ramipril and aspirin as the bulk drug and in combined capsule dosage Forms

Patole MS, et al.

International Journal of Pharmaceutical Sciences Review and Research, 4(3), 40-45 (2010)

A Spectrophotometric method for the determination of ramipril in solid dosage forms

Afleroho EO, et al.

Tropical Journal of Pharmaceutical Research, 11(2), 275-279 (2012)

Simultaneous determination of ramipril, hydrochlorothizide and telmisartan by spectrophotometry

Bankey S, et al.

International Journal of ChemTech Research, 1(2), 183-188 (2009)

Statistical optimization and in-vitro evaluation of hollow microcapsules of an anti-hypertensive agent.

Tushar A Premchandani et al.

Acta poloniae pharmaceutica, 71(1), 95-106 (2014-05-02)

The present work attempts to formulate and evaluate hollow microcapsules of an antihypertensive drug--ramipril, which will remain in vicinity of absorption site. The emulsion diffusion solvent evaporation method was employed for preparation of microspheres using Eudragit E100. Glycerol monostearate and

Ramipril and metoprolol intake aggravate human and murine anaphylaxis: evidence for direct mast cell priming.

Maria Nassiri et al.

The Journal of allergy and clinical immunology, 135(2), 491-499 (2014-12-03)

Cofactors contribute to the elicitation of anaphylaxis. β-Blockers and angiotensin-converting enzyme (ACE) inhibitors are widely used cardiovascular drugs. We specially designed a mouse model to further analyze the cofactor potential of these drugs. We sought to test the hypothesis that

Development and validation of simultaneous HPLC method for estimation of telmisartan and ramipril in pharmaceutical formulations

Jawla S, et al.

International Journal of PharmTech Research, 2(2), 1625-1633 (2010)

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