PHR1472

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Showing 1-20 of 20 results for "PHR1472" within Papers

Conversion of solid dispersion prepared by acid-base interaction into free-flowing and tabletable powder by using Neusilin® US2.

Ankita Shah et al.

International journal of pharmaceutics, 484(1-2), 172-180 (2015-03-01)

A novel method of greatly increasing solubility and dissolution rate of a model basic drug, haloperidol, by interacting it with water-soluble weak organic acids in aqueous media was previously reported in the literature. Amorphous solid dispersion (SD) was formed when

Differentiation of South American crack and domestic (US) crack cocaine via headspace-gas chromatography/mass spectrometry.

Valerie L Colley et al.

Drug testing and analysis, 7(3), 241-246 (2014-10-11)

South American 'crack' cocaine, produced directly from coca leaf, can be distinguished from US domestically produced crack on the basis of occluded solvent profiles. In addition, analysis of domestically produced crack indicates the solvents that were used for cocaine hydrochloride

Enological Chemistry, 4(8), 1819-1824 (2012)

Bitterness evaluation of acidic pharmaceutical substances (NSAIDs) using a taste sensor.

Miyako Yoshida et al.

Chemical & pharmaceutical bulletin, 62(12), 1252-1258 (2014-12-03)

The objective of this study was to evaluate an improved bitterness sensor which has been developed to allow the precise and sensitive prediction of the bitterness of acidic bitter pharmaceutical active ingredients, using as examples nine non-steroidal anti-inflammatory drugs (NSAIDs).

Optimization and application of headspace-solid-phase micro-extraction coupled with gas chromatography-mass spectrometry for the determination of volatile compounds in cherry wines.

Zuobing Xiao et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 122-130 (2014-12-30)

A simple, rapid and solvent-free multi-residue method has been developed and applied to confirm and quantify a series of volatile compounds in five cherry wines by gas chromatography coupled with mass spectrometry (GC-MS). Four parameters (e.g., coating material of fiber

O-Monoacyltartaric acid catalyzed enantioselective conjugate addition of a boronic acid to dienones: application to the synthesis of optically active cyclopentenones.

Masaharu Sugiura et al.

Organic letters, 16(19), 5172-5175 (2014-09-24)

Enantioselective conjugate addition of styrylboronic acid to dienones was effectively catalyzed by an O-monoacyltartaric acid to afford monostyrylated products with good enantioselectivity. The RCM of the monostyrylated products using the Hoveyda-Grubbs II catalyst afforded optically active cyclopentenones, including a synthetic

Encyclopaedia of Occupational Health and Safety: Industries and Occupations, 4(8), 1819-1824 (1998)

Enhanced ALP activity of MG63 cells cultured on hydroxyapatite-poly(ethylene glycol) hydrogel composites prepared using EDTA-OH.

Temmei Ito et al.

Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)

In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)

Exogenous acetaldehyde as a tool for modulating wine color and astringency during fermentation.

Marlena K Sheridan et al.

Food chemistry, 177, 17-22 (2015-02-11)

Wine tannins undergo modifications during fermentation and storage that can decrease their perceived astringency and increase color stability. Acetaldehyde acts as a bridging compound to form modified tannins and polymeric pigments that are less likely to form tannin-protein complexes than

Fluorescent carbon nanodots for sensitive and selective detection of tannic acid in wines.

Gaber Hashem Gaber Ahmed et al.

Talanta, 132, 252-257 (2014-12-06)

Herein we describe an easy one step synthesis of carbon nanodots (C-dots) by thermal carbonization of 6-bromohexylboronic acid using two different amine compounds, polyethyleneglycol bis(3-aminopropyl (PEGA) and 1,2-aminopropane (DPA), at 180 °C in atmospheric oxygen. The as-synthesized C-dots were characterized

Decellularized cartilage-derived matrix as substrate for endochondral bone regeneration.

Debby Gawlitta et al.

Tissue engineering. Part A, 21(3-4), 694-703 (2014-10-16)

Following an endochondral approach to bone regeneration, multipotent stromal cells (MSCs) can be cultured on a scaffold to create a cartilaginous callus that is subsequently remodeled into bone. An attractive scaffold material for cartilage regeneration that has recently regained attention

Construction of a high-density genetic map and QTLs mapping for sugars and acids in grape berries.

Jie Chen et al.

BMC plant biology, 15, 28-28 (2015-02-04)

QTLs controlling individual sugars and acids (fructose, glucose, malic acid and tartaric acid) in grape berries have not yet been identified. The present study aimed to construct a high-density, high-quality genetic map of a winemaking grape cross with a complex

Monocyte CD40 expression in young healthy female smokers and/or oral contraceptives users without additional risk factors for atherosclerosis.

Mariana S Parahuleva et al.

Thrombosis research, 135(2), 260-266 (2014-12-30)

Atherosclerosis, as an inflammatory disease, is characterized by pathologically altered levels of cytokines. We investigated whether smoking and/or oral contraceptives (OCs) affect the CD40/CD40L plasma levels and expression in young females without other risk factors for atherosclerosis. A case-control single-center

Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474.

Sho Isoyama et al.

Cancer science, 106(2), 171-178 (2014-12-09)

Drug resistance often critically limits the efficacy of molecular targeted drugs. Although pharmacological inhibition of phosphatidylinositol 3-kinase (PI3K) is an attractive therapeutic strategy for cancer therapy, molecular determinants for efficacy of PI3K inhibitors (PI3Kis) remain unclear. We previously identified that

Sensitive determination of periodate and tartaric acid by stopped-flow chemiluminescence spectrometry

Gaikwad A, et al.

Analyst, 119(8), 1819-1824 (1994)

The Leishmania donovani histidine acid ecto-phosphatase LdMAcP: insight into its structure and function.

Amalia Papadaki et al.

The Biochemical journal, 467(3), 473-486 (2015-02-20)

Acid ecto-phosphatase activity has been implicated in Leishmania donovani promastigote virulence. In the present study, we report data contributing to the molecular/structural and functional characterization of the L. donovani LdMAcP (L. donovani membrane acid phosphatase), member of the histidine acid

Establishment of optimized in vitro assay methods for evaluating osteocyte functions.

Masashi Honma et al.

Journal of bone and mineral metabolism, 33(1), 73-84 (2014-01-02)

Recent studies have revealed that osteocytes play multiple important physiological roles. To analyze osteocyte functions in detail, an in vitro experimental system for primary osteocytes would be useful. Unfortunately, osteocytes tend to dedifferentiate and acquire osteoblast-like features even when the

Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.

Yan Chen et al.

Current biology : CB, 24(17), 1969-1977 (2014-08-19)

Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and

Selective removal of phosphate for analysis of organic acids in complex samples.

Sandeep Deshmukh et al.

Journal of chromatography. A, 1388, 1-8 (2015-03-01)

Accurate quantitation of compounds in samples of biological origin is often hampered by matrix interferences one of which occurs in GC-MS analysis from the presence of highly abundant phosphate. Consequently, high concentrations of phosphate need to be removed before sample

Urinary tartaric acid as a potential biomarker for the dietary assessment of moderate wine consumption: a randomised controlled trial.

Jorge Regueiro et al.

The British journal of nutrition, 111(9), 1680-1685 (2014-02-11)

The availability of biomarkers that allow the estimation of the intake of specific foods and dietary components, as an alternative or addition to self-reported dietary questionnaires, could greatly enhance the effectiveness of nutritional research. The aim of the present study

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