PRS4877

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Showing 1-8 of 8 results for "PRS4877" within Papers

Cytokine production by human neutrophils: Revisiting the "dark side of the moon".

Nicola Tamassia et al.

European journal of clinical investigation, 48 Suppl 2, e12952-e12952 (2018-05-18)

Polymorphonuclear neutrophils are the most numerous leucocytes present in human blood, and function as crucial players in innate immune responses. Neutrophils are indispensable for the defence towards microbes, as they effectively counter them by releasing toxic enzymes, by synthetizing reactive

IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection

Tsai HC, et al.

Clinical & Developmental Immunology (2013)

Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects

Wang M, et al.

Human immunology, 73(6), 647-653 (2012)

Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat

Ichiyama K, et al.

The Journal of Biological Chemistry, 283(25), 17003-17008 (2008)

Dysfunction of regulatory T cells mediated by AKT-FOXO1 signaling pathway occurs during the development of psoriasis.

Zhixia Fan et al.

International journal of clinical and experimental pathology, 13(4), 799-809 (2020-05-02)

Psoriasis is an immune-mediated skin disease with abnormal T cells. Regulatory T cells (Treg) are a kind of cell group with immunosuppressive effects. This study aimed to explore the role of Treg cells in the pathogenesis of psoriasis and its

A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect It.

Nicola Tamassia et al.

Frontiers in immunology, 9, 795-795 (2018-05-03)

Neutrophils are known to perform a series of effector functions that are crucial for the innate and adaptive responses, including the synthesis and secretion of a variety of cytokines. In light of the controversial data in the literature, the main

A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry.

Francesca Tamarozzi et al.

Immunology letters, 162(2 Pt B), 194-198 (2014-12-03)

We identified IL-17A-positive neutrophils in Wolbachia-positive Onchocerca volvulus nodules using an antibody that has previously reported IL-17A-positive neutrophils in several inflammatory conditions. However, we could not detect IL-17A using a range of alternative assays. Our data question the IL-17A antibody

Calcitriol inhibits osteoclastogenesis in an inflammatory environment by changing the proportion and function of T helper cell subsets (Th2/Th17).

Chun-Sheng Bi et al.

Cell proliferation, 53(6), e12827-e12827 (2020-05-15)

Previously, we found that by regulating T helper (Th) cell polarization, calcitriol intervention inhibited lipopolysaccharide (LPS)-induced alveolar bone loss in an animal periodontitis model, but the underlying cellular events remain unknown. In this study, mouse Th cells were incubated in

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