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Showing 1-13 of 13 results for "RAB0202" within Papers
Wang Liao et al.
Diabetes, 70(3), 696-709 (2021-01-08)
The liver is a key player for maintaining glucose homeostasis. Excessive hepatic glucose production is considered to be a key for the onset of type 2 diabetes. The primary function of heme oxygenase-1 (HO1) is to catalyze the degradation of
Dina Medina-Vera et al.
Nutrients, 13(7) (2021-07-03)
D-Pinitol (DPIN) is a natural occurring inositol capable of activating the insulin pathway in peripheral tissues, whereas this has not been thoroughly studied in the central nervous system. The present study assessed the potential regulatory effects of DPIN on the
Ruochan Chen et al.
Hepatology (Baltimore, Md.), 67(5), 1823-1841 (2017-11-18)
Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver tumor metabolic reprogramming remains elusive. Here, we provide evidence that high mobility group
Diabetogenic Effects of Ochratoxin A in Female Rats
Mor F, et al.
Toxins, 9(4), 144-144 (2017)
Olga Barca-Mayo et al.
Glia, 68(6), 1131-1147 (2019-12-14)
Disruption of the circadian cycle is strongly associated with metabolic imbalance and reduced longevity in humans. Also, rodent models of circadian arrhythmia, such as the constitutive knockout of the clock gene Bmal1, leads to metabolic disturbances and early death. Although
Rachel J Perry et al.
The Journal of clinical investigation, 127(2), 657-669 (2017-01-24)
The mechanism by which leptin reverses diabetic ketoacidosis (DKA) is unknown. We examined the acute insulin-independent effects of leptin replacement therapy in a streptozotocin-induced rat model of DKA. Leptin infusion reduced rates of lipolysis, hepatic glucose production (HGP), and hepatic
Sangam Rajak et al.
Molecular metabolism, 53, 101286-101286 (2021-07-06)
Crinophagy is a secretory granule-specific autophagic process that regulates hormone content and secretion in endocrine cells. However, despite being one of the earliest described autophagic processes, its mechanism of action and regulation in mammalian cells remains unclear. Here, we examined
Yousef Manialawy et al.
The Journal of biological chemistry, 295(29), 9879-9892 (2020-05-23)
Type 2 diabetes is a chronic metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance. Among individuals with type 2 diabetes, ∼30% exhibit hypomagnesemia. Hypomagnesemia has been linked to insulin resistance through reduced tyrosine kinase activity of the
Firdevs Mor et al.
Toxins, 9(4) (2017-04-20)
In this study, the diabetogenic effects of long term Ochratoxin A (OTA) administration in rats were investigated, and its role in the etiology of diabetes mellitus (DM) was examined utilizing 42 female Wistar rats for these purposes. The rats were
Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice
Barca-Mayo O, et al.
Glia, 68(6), 1131-1147 (2020)
Gregory G Martin et al.
Lipids, 55(4), 309-327 (2020-04-22)
Ad libitum-fed diets high in fat and carbohydrate (especially fructose) induce weight gain, obesity, and nonalcoholic fatty liver disease (NAFLD) in humans and animal models. However, interpretation is complicated since ad libitum feeding of such diets induces hyperphagia and upregulates
High mobility group protein B1 controls liver cancer initiation through yes-associated protein-dependent aerobic glycolysis
Chen R, et al.
Hepatology, 67(5), 1823-1841 (2018)
Joseph F Pierre et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(6), G431-G442 (2015-07-18)
Stimulation of digestive organs by enteric peptides is lost during total parental nutrition (PN). Here we examine the role of the enteric peptide bombesin (BBS) in stimulation of the exocrine and endocrine pancreas during PN. BBS protects against exocrine pancreas
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