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Showing 1-13 of 13 results for "RAB0281" within Papers
Agatha S Critchfield et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(10), 1266-1273 (2014-02-13)
To evaluate the biocompatibility of silk gel for cervical injection. Silk gel was injected into the cervix of pregnant rats on day 13 (n = 11) and harvested at day 17. Histology of silk gel was compared with suture controls.
Jin-Sung Chung et al.
The Journal of investigative dermatology, 134(11), 2784-2794 (2014-06-18)
A major barrier to successful cancer immunotherapy is the tumor's ability to induce T-cell tolerance by exploiting host regulatory mechanisms. Having discovered the DC-HIL receptor, which inhibits T-cell responses by binding to syndecan-4 on effector T cells, we posited the
Tara M Weitz et al.
The American journal of pathology, 184(11), 2855-2861 (2014-09-02)
Activated microglia are associated with amyloid plaques in transgenic mouse models of cerebral amyloidosis and in human Alzheimer disease; yet, their implication in Alzheimer disease pathogenesis remains unclear. It has been suggested that microglia play dual roles depending on the
D M Bailey et al.
Acta physiologica (Oxford, England), 212(2), 175-187 (2014-05-09)
The aim of this study was to examine if erythropoietin (EPO) has the potential to act as a biological antioxidant and determine the underlying mechanisms. The rate at which its recombinant form (rHuEPO) reacts with hydroxyl (HO˙), 2,2-diphenyl-1-picrylhydrazyl (DPPH˙) and
Jere Lindén et al.
International journal of molecular sciences, 15(8), 13938-13966 (2014-08-15)
One of the hallmarks of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a drastically reduced feed intake by an unknown mechanism. To further elucidate this wasting syndrome, we followed the effects of a single large dose (100 μg/kg) of TCDD
Jason M Correnti et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(11), G959-G973 (2014-04-20)
Hepatosteatosis, the ectopic accumulation of lipid in the liver, is one of the earliest clinical signs of alcoholic liver disease (ALD). Alcohol-dependent deregulation of liver ceramide levels as well as inhibition of AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor
Changchun Cai et al.
Hepatology (Baltimore, Md.), 60(3), 990-1002 (2014-05-07)
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure in industrialized countries. Understanding the mechanisms of APAP-induced liver injury as well as other forms of sterile liver injury is critical to improve the care of patients. Recent
Ryan W Walker et al.
Obesity (Silver Spring, Md.), 22(6), 1512-1519 (2014-03-13)
Obesity in childhood is associated with an inflammatory state in adipose tissue and liver, which elevates risk for diabetes and liver disease. No prior study has examined associations between pathologies occurring in adipose tissue and liver to identify elements of
Yu-Sheng Fang et al.
Nature communications, 5, 4824-4824 (2014-09-13)
Proteinaceous inclusions are common hallmarks of many neurodegenerative diseases. TDP-43 proteinopathies, consisting of several neurodegenerative diseases, including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS), are characterized by inclusion bodies formed by polyubiquitinated and hyperphosphorylated full-length and truncated TDP-43.
Ill-Hwa Kim et al.
Theriogenology, 82(3), 427-432 (2014-06-17)
The objective of this study was to compare the concentrations of inflammatory cytokines in uterine flush and serum from healthy postpartum dairy cows and cows with clinical or subclinical endometritis. Clinical endometritis was diagnosed by observation of vaginal discharges (>50%
Jonathan P Little et al.
Molecular and cellular neurosciences, 60, 88-96 (2014-04-29)
Microglia represent mononuclear phagocytes in the brain and perform immune surveillance, recognizing a number of signaling molecules released from surrounding cells in both healthy and pathological situations. The microglia interact with several damage-associated molecular pattern molecules (DAMPs) and recent data
Somiraa S Said et al.
Pharmaceutical research, 31(12), 3335-3347 (2014-05-24)
For building functional vasculature, controlled delivery of fibroblast growth factor-9 (FGF9) from electrospun fibers is an appealing strategy to overcome challenges associated with its short half-life. FGF9 sustained delivery could potentially drive muscularization of angiogenic sprouts and help regenerate stable
Diana A Alvarez Arias et al.
Cancer immunology research, 2(3), 207-216 (2014-04-30)
Tumor growth is associated with the inhibition of host antitumor immune responses that can impose serious obstacles to cancer immunotherapy. To define the potential contribution of Qa-1-restricted CD8 regulatory T cells (Treg) to the development of tumor immunity, we studied
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