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[Tin compounds in pharmacy and nutrition].

[Tin compounds in pharmacy and nutrition].

Acta pharmaceutica Hungarica (2001-02-24)

L Nagy, A Szorcsik, K Kovács

ABSTRACT

The occurrence of tin in plants, animals and humans is discussed, in relation to its abundance in the lithosphere and hydrosphere and the range of the different tin(II) and tin(IV) complexes formed. A reasoned consideration of its essentiality for living species is provided. It is concluded that tin is beneficial, even if not yet proved to be an essential element. After reference to the chemistry of tin compounds, there is a detailed discussion of their toxicity in animals and humans. Feasible routes for tin intake and uptake into humans are described. The past and current use of tin pharmaceuticals is reviewed and the areas for which they are currently permitted for use in humans as dentifrices and mouth washes, as radio-pharmaceuticals and for the treatment of jaundiced newborns are described. A detailed review of tin-containing antitumour agents as representative tin pharmaceuticals is also given. Finally, a list of tin-containing drugs and drug candidates is also shown.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Tin, nanopowder, <150 nm particle size (SEM), ≥99% trace metals basis

Sigma-Aldrich

Tin, powder, 10 μm, 99% trace metals basis

Sigma-Aldrich

Tin, granular, 0.425-2.0 mm particle size, ≥99.5%, ACS reagent

Sigma-Aldrich

Tin, foil, thickness 0.127 mm, 99.9%

Sigma-Aldrich

Tin, ≥99%, powder

Sigma-Aldrich

Tin, powder, <150 μm, 99.5% trace metals basis

Sigma-Aldrich

Tin, powder, -100 mesh, 99.99% trace metals basis

Tin, foil, light tested, 50x50mm, thickness 0.008mm, 99.75%

Tin, foil, not light tested, 150x150mm, thickness 0.007mm, 97.4%

Tin, foil, not light tested, 150x150mm, thickness 0.009mm, 97.4%

Tin, foil, not light tested, 25x25mm, thickness 0.006mm, 99.75%

Tin, foil, 25mm disks, thickness 0.15mm, as rolled, 98.8%

Tin, foil, 300x300mm, thickness 1.0mm, as rolled, 98.8%

Tin, foil, 15mm disks, thickness 0.008mm, 99.75%

Tin, foil, 50mm disks, thickness 0.25mm, as rolled, 99.99+%

Tin, foil, 10mm disks, thickness 0.1mm, as rolled, 99.95%

Tin, foil, 15mm disks, thickness 0.25mm, as rolled, 98.8%

Tin, foil, 10mm disks, thickness 1.0mm, as rolled, 100%

Tin, foil, 10mm disks, thickness 0.02mm, 99.75%

Tin, foil, 15mm disks, thickness 0.025mm, as rolled, 99.99+%

Tin, foil, 10mm disks, thickness 1.0mm, as rolled, 99.99+%

Tin, foil, 10m coil, thickness 0.109mm, coil width 41mm, as rolled, 99.95%

Tin, foil, 15mm disks, thickness 0.009mm, 97.4%

Tin, foil, 0.5m coil, thickness 0.125mm, as rolled, 98.8%

Tin, foil, 300x300mm, thickness 2.0mm, as rolled, 98.8%

Tin, foil, 300x300mm, thickness 0.5mm, as rolled, 98.8%

Tin, foil, 15mm disks, thickness 0.02mm, 99.75%

Tin, foil, 20m coil, thickness 0.096mm, coil width 41mm, as rolled, 99.95%

Tin, foil, 10mm disks, thickness 0.05mm, as rolled, 99.99+%

Tin, foil, 1m coil, thickness 0.025mm, as rolled, 98.8%