Understanding platinum-induced ototoxicity.

Understanding platinum-induced ototoxicity.

Trends in pharmacological sciences (2013-06-19)

Thorsten Langer, Antoinette am Zehnhoff-Dinnesen, Susanne Radtke, Johannes Meitert, Oliver Zolk

ABSTRACT

Childhood cancer survival rates are now nearly 80% in more developed European countries because of improved therapies and better supportive care. Platinum chemotherapy drugs, such as cisplatin and carboplatin, are the cornerstone of many effective therapeutic protocols for childhood cancer. However, the antitumor efficacy of cisplatin and carboplatin comes at the cost of ototoxicity, which affects at least 60% of pediatric patients. Although ototoxicity is not life threatening, it can have debilitating effects on patients' quality of life. Recently, many initiatives have been launched with the ultimate goal of reducing cisplatin and high-dose carboplatin ototoxicity without compromising antitumor efficacy. This review addresses the incidence of platinum ototoxicity and its clinical presentation, time course, and early diagnostic evaluation. Genetic and non-genetic risk factors for platinum-associated ototoxicity, and their predictive value, are discussed. Recent developments in the prevention of platinum ototoxicity are also summarized.

MATERIALS

Product Number

Brand

Product Description

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

GF30985050

Platinum, tube, 50mm, outside diameter 6mm, inside diameter 5.6mm, wall thickness 0.2mm, as drawn, 99.95%

GF94628852

Platinum, tube, 500mm, outside diameter 0.5mm, inside diameter 0.42mm, wall thickness 0.04mm, as drawn, 99.95%

GF92036235

Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.99+%

GF96551354

Platinum, foil, 10mm disks, thickness 0.0075mm, as rolled, 99.95%

GF30259357

Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.95%

GF04529538

Platinum, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%

GF19085058

Platinum, foil, 4mm disks, thickness 0.025mm, as rolled, 99.99+%

GF26290313

Platinum, tube, 50mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%

GF61547632

Platinum, foil, 8mm disks, thickness 0.01mm, as rolled, 99.95%

GF85632408

Platinum, foil, 6mm disks, thickness 0.025mm, as rolled, 99.99+%

GF73706058

Platinum, foil, 10mm disks, thickness 0.0125mm, as rolled, 99.95%

GF19578831

Platinum, wire reel, 0.05m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%

GF48496977

Platinum, foil, 4mm disks, thickness 0.125mm, as rolled, 99.99+%

GF72566657

Platinum, foil, 0.1m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF59323619

Platinum, foil, 15mm disks, thickness 0.01mm, as rolled, 99.95%

GF00187163

Platinum, foil, 0.1m coil, thickness 0.15mm, coil width .9mm, as rolled, 99.99%

GF55534046

Platinum, foil, 0.05m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF68611237

Platinum, foil, 0.2m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF03272868

Platinum, foil, 4mm disks, thickness 0.125mm, as rolled, 99.95%

GF09598809

Platinum, foil, 0.5m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF48335519

Platinum, wire reel, 0.2m, diameter 0.6mm, as drawn, 99.99+%

GF43907799

Platinum, foil, 15mm disks, thickness 0.005mm, as rolled, 99.95%

GF72782231

Platinum, foil, 50x50mm, thickness 0.1mm, as rolled, 99.99+%