Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.

Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.

Bioorganic & medicinal chemistry letters (2001-04-11)

S Ishibuchi, H Morimoto, T Oe, T Ikebe, H Inoue, A Fukunari, M Kamezawa, I Yamada, Y Naka

ABSTRACT

A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.

MATERIALS

Product Number

Brand

Product Description

59586-U

Supelco

Discovery^®Cyano Supelguard Cartridge, 5 μm particle size, L × I.D. 2 cm × 4 mm

59357-U

Supelco

Discovery^® Cyano HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm

59356-U

Supelco

Discovery^® Cyano HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

59357-U40

Supelco

Discovery^® Cyano HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4 mm