Aqueous Sample Matrix/Mobile Phase Environment
Basic Steps
SPE Tips
Reversed-phase SPE is considered the least selective retention mechanism when compared to normalphase or ion-exchange SPE. In other words, it may be difficult for a reversed-phase method or bonded chemistry to differentiate between molecules that are structurally similar. However, because reversed-phase will retain most molecules with any hydrophobic character, it is very useful for extracting analytes that are very diverse in structure within the same sample.
Figure 1.Aqueous Sample Matrix/Mobile Phase Environment
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