During formulation development of oral solid dosage forms, complex challenges such as instability of APIs and API processing are on the rise. Due to its various functionalities, the multi-talent polyvinyl alcohol (PVA) offers effective solutions to these challenges. Beyond classical applications as a matrix polymer or coating component, the versatile polymer can be effectively used in orodispersible films and is well suited for hot melt extrusion, spray drying, continuous manufacturing and 3D printing technologies.
This webinar provides you with technical insights on how PVA can be used in a broad range of solid applications to meet future trends in formulation development.
In this webinar, you will learn:
- How to master consistent drug delivery over long release periods by the use of PVA in sustained release formulations
- How to tackle challenges with poorly APIs by the use of hot melt extrusion, spray drying and 3D printing technologies
- How high process efficiency and stable granules can be achieved with PVA as a binder for wet granulation in continuous manufacturing
- How PVA can be effectively used in orodispersible film applications enabling a rapid dissolution of the API and easy intake by patients
Speakers
Markus Lubda, Ph.D.
Merck
Strategic Business Manager
Markus is a biomolecular engineer. He is responsible for the strategic development and positioning of an excipient portfolio for oral solid dosage form applications. Thereby, the focus is to enhance solubility and bioavailability of the most challenging APIs with specifically engineered excipients for oral solid application. He holds a Ph.D. in biology/chemistry from the Technical University of Darmstadt and is a biomolecular engineer.
Lena Mueller, Ph.D.
Merck
Senior Laboratory Manager
Lena is a pharmacist by training (University of Kiel) with a Ph.D. in organic chemistry and biochemistry (TU Darmstadt). As Head of functional excipients, she leads a team that concentrates on the development and application of functional excipients designed for oral delivery. Solubility enhancement of poorly soluble APIs, continuous manufacturing and the delivery of large molecules are the focus areas of the lab team.
Pharma and biopharma manufacturing
- Solid Formulation Strategies
期间:1h 31min
语言:English
场次 1:往期 January 25, 2024
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