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HomeWebinarsReady-to-Use Raman for Upstream Monitoring — Expanding Insights into Downstream & Novel Modalities

Ready-to-Use Raman for Upstream Monitoring — Expanding Insights into Downstream & Novel Modalities



WEBINAR

Raman spectroscopy is an effective analytical technique for in-line, real-time monitoring of cell culture parameters, requiring a calibration phase that can be resource-intensive and time-consuming. Ready-to-use models directly embedded into the Raman analyzer simplify calibration. Users can bypass extensive model development and begin monitoring for immediate insights.

This webinar presents findings from fed-batch and perfusion cell culture runs utilizing ready-to-use models for in-line, real-time measurement of glucose, lactate and mAb titer. The capabilities of on-line Raman sensor for critical attributes monitoring in downstream & new modalities areas will be also highlighted.

In this webinar, you will learn:

  • How plug-and-play models embedded into a Raman analyzer simplify the calibration workflow
  • Applications of ready-to-use models in monitoring glucose, lactate, and monoclonal antibody (mAb) titer during cell culture runs
  • How the Transfer Learning Algorithms (TLA) refines and improves the initial models
  • How to streamline the implementation of Raman technology in Chromatography and Tangential Flow Filtration (TFF)

Speakers

Fabrice Thomas

Fabrice Thomas

Merck

Senior R&D Manager - PAT Raman Technology

Fabrice Thomas has more than 10 years of experience in the development of cutting-edge spectroscopic technologies for challenging industries and in complex R&D project management. As Sr. R&D manager for Process Analytical Technologies (PAT) at our company, Fabrice's work focuses on the development and implementation of a GMP-ready Raman PAT platform to facilitate process monitoring in the biopharma industry from process development to manufacturing. He holds an M.S. in engineering physics and a Ph.D. from the University Grenoble Alpes, France.

Kevin Grollier

Kevin Grollier

Merck

PAT Implementation & Support Engineer

Kevin Grollier graduated from the Lyon Pharmaceutical Industry Institute (IPIL), with an M.S. in pharmaceutical production specializing in biotechnology. At our company, he is a PAT implementation and support engineer in charge of implementing Raman projects at customer sites, training ProCellics™ Raman Analyzer users, and providing technical support on hardware, software, and data analysis topics. Before joining our company, he worked at Merial (now BIAH) as a QA validation engineer where he had the opportunity to work on various validation projects.

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