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Merck
CN

ABCC8

ATP-binding cassette, sub-family C (CFTR/MRP), member 8

别名:
ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, SUR1delta2, TNDM2
物种:
UniProtKB ID:
基因ID:
  • Human(6833) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq, Jul 2008]
  • Mouse(20927) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • Rat(25559) ATP-binding cassette, subfamily C (CFTR/MRP), member 8
  • domestic cat(101096101) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • sheep(101120522) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • naked mole-rat(101705546) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • domestic guinea pig(100722700) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • Zebrafish(553281) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • chicken(423072) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • dog(485402) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • Horse(100071788) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • cow(538996) ATP-binding cassette, sub-family C (CFTR/MRP), member 8

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Antibodies

货号
说明
物种反应性
应用
Anti-SUR1 Antibody, clone N289/16, clone N289/16, from mouse,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
Monoclonal Anti-Sur1 - Atto 594 antibody produced in mouse, clone S289-16, purified immunoglobulin,
物种反应性
hamster, mouse, rat
应用
immunocytochemistry
immunohistochemistry

western blot
Anti-SUR1/ABCC8 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
canine, human, mouse, rat
应用
ELISA
western blot
Anti-ABCC8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
Monoclonal Anti-Sur1 - Atto 488 antibody produced in mouse, clone S289-16, purified immunoglobulin,
物种反应性
hamster, mouse, rat
应用
immunocytochemistry
immunohistochemistry

western blot

Small Molecule - Blocker

货号
说明
物种
格列本脲, United States Pharmacopeia (USP) Reference Standard,
物种
human
甲苯磺丁脲, United States Pharmacopeia (USP) Reference Standard,
物种
human
格列本脲, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
格列美脲, United States Pharmacopeia (USP) Reference Standard,
物种
human
Tolazamide, United States Pharmacopeia (USP) Reference Standard,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Abcc8,
物种
mouse
MISSION® esiRNA, targeting human ABCC8,
物种
human