GP1BB
glycoprotein Ib (platelet), beta polypeptide
别名:
BDPLT1, BS, CD42C, GPIBB
物种:
Human GP1BB (2812), Mouse Gp1bb (14724), Rat Gp1bb (116727), cow GP1BB (100298963), domestic cat GP1BB (101080743), chicken GP1BB (416780), naked mole-rat Gp1bb (101717047), domestic guinea pig Gp1bb (100735782), Zebrafish gp1bb (798998), dog GP1BB (608234)
UniProtKB ID:
基因ID:
- Human(2812) Summary: Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene. [provided by RefSeq, Dec 2010]
- Mouse(14724) glycoprotein Ib, beta polypeptide
- Rat(116727) glycoprotein Ib (platelet), beta polypeptide
- cow(100298963) glycoprotein Ib (platelet), beta polypeptide
- domestic cat(101080743) glycoprotein Ib (platelet), beta polypeptide
- chicken(416780) glycoprotein Ib (platelet), beta polypeptide
- naked mole-rat(101717047) glycoprotein Ib (platelet), beta polypeptide
- domestic guinea pig(100735782) glycoprotein Ib (platelet), beta polypeptide
- Zebrafish(798998) glycoprotein Ib (platelet), beta polypeptide
- dog(608234) glycoprotein Ib (platelet), beta polypeptide
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Antibodies
Product Number
说明
物种反应性
应用
ANTI-GP1BB (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human
应用
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot