GSAP
gamma-secretase activating protein
别名:
PION
物种:
Human GSAP (54103), Mouse Gsap (212167), Rat Gsap (311984), naked mole-rat Gsap (101697045), domestic guinea pig Gsap (100725299), Zebrafish gsap (100151358)
UniProtKB ID:
基因ID:
- Human(54103) Summary: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]
- Mouse(212167) gamma-secretase activating protein
- Rat(311984) gamma-secretase activating protein
- naked mole-rat(101697045) gamma-secretase activating protein
- domestic guinea pig(100725299) gamma-secretase activating protein
- Zebrafish(100151358) gamma-secretase activating protein
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