LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
别名:
SLP-76, SLP76
物种:
Human LCP2 (3937), Mouse Lcp2 (16822), Rat Lcp2 (155918), dog LCP2 (489126), domestic cat LCP2 (101096877), domestic guinea pig Lcp2 (100718602), fruit fly Lcp2 (35818), chicken LCP2 (395438), sheep LCP2 (101105277), cow LCP2 (513244) ...展开
UniProtKB ID:
基因ID:
- Human(3937) Summary: SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008]
- Mouse(16822) lymphocyte cytosolic protein 2
- Rat(155918) lymphocyte cytosolic protein 2
- dog(489126) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- domestic cat(101096877) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- domestic guinea pig(100718602) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- fruit fly(35818) Larval cuticle protein 2
- chicken(395438) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- sheep(101105277) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- cow(513244) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- Horse(100059274) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- Domestic Rabbit(100339465) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- naked mole-rat(101705208) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
说明
物种反应性
应用
Monoclonal Anti-SLP76 antibody produced in mouse, clone SLP-76/03,
物种反应性
human, mouse, pig
应用
western blot
Anti-LCP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-LCP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-SLP76 Antibody, from rabbit, purified by affinity chromatography,
物种反应性
human, rhesus macaque
应用
immunoprecipitation (IP)
western blot
western blot
esiRNA
Product Number
说明
物种