RASGRP4
RAS guanyl releasing protein 4
别名:
物种:
Human RASGRP4 (115727), Mouse Rasgrp4 (233046), Rat Rasgrp4 (170668), Domestic Rabbit RASGRP4 (100350559), domestic guinea pig Rasgrp4 (100727572), naked mole-rat Rasgrp4 (101708596), Zebrafish rasgrp4 (558453), domestic cat RASGRP4 (101094467), dog RASGRP4 (484528), cow RASGRP4 (529375)
UniProtKB ID:
基因ID:
- Human(115727) Summary: The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
- Mouse(233046) RAS guanyl releasing protein 4
- Rat(170668) RAS guanyl releasing protein 4
- Domestic Rabbit(100350559) RAS guanyl releasing protein 4
- domestic guinea pig(100727572) RAS guanyl releasing protein 4
- naked mole-rat(101708596) RAS guanyl releasing protein 4
- Zebrafish(558453) RAS guanyl releasing protein 4
- domestic cat(101094467) RAS guanyl releasing protein 4
- dog(484528) RAS guanyl releasing protein 4
- cow(529375) RAS guanyl releasing protein 4
- sheep(101112342) RAS guanyl releasing protein 4
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Antibodies
产品编号
说明
物种反应性
应用
Monoclonal Anti-RASGRP4 antibody produced in mouse, clone 1F3, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-RASGRP4, (C-terminal) antibody produced in mouse, clone 6D3, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-RASGRP4 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
proximity ligation assay
western blot
western blot