CN

668524

Sigma-Aldrich

(+)-1,2-双[(2R,5R)-2,5-二异丙基磷]苯

kanata purity

别名:
(R,R)-i-Pr-DUPHOS
Empirical Formula (Hill Notation):
C26H44P2
CAS号:
分子量:
418.58
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

质量水平

100

旋光性

[α]20/D +103°, c = 1 in chloroform

折射率

n20/D 1.5701

SMILES string

CC(C)[C@H]1CC[C@H](C(C)C)P1c2ccccc2P3[C@H](CC[C@@H]3C(C)C)C(C)C

InChI

1S/C26H44P2/c1-17(2)21-13-14-22(18(3)4)27(21)25-11-9-10-12-26(25)28-23(19(5)6)15-16-24(28)20(7)8/h9-12,17-24H,13-16H2,1-8H3/t21-,22-,23-,24-/m1/s1

InChI key

RBVGOQHQBUPSGX-MOUTVQLLSA-N

一般描述

旋光度偏差 ± 13

应用

(R,R)-i-Pr-DUPHOS is a chiral phospholane class of ligand that can be used in:
  • The catalytic asymmetric hydrogenation reactions.
  • Rhodium catalyzed enantioselective synthesis of 1,2 diols via asymmetric intramolecular hydrosilylation of α- and β-hydroxyketones.
  • In the enantioselective synthesis of diarylmethanols by arylation of aromatic aldehydes with arylboronic acids in the presence of a rhodium catalyst.

包装

100 mg in clear glass bottle
500 mg in amber glass bottle

法律信息

与 Kanata Chemical Technologies Inc. 联合销售,仅供研究使用。这些化合物由 E.I. du Pont de Nemours and Company 授权制造和销售,此许可不包括利用这些化合物制备在制药领域销售的产品的权利。

个人防护装备

Eyeshields, Gloves, type N95 (US)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

闪点(F)

230.0 °F

闪点(C)

> 110 °C

分析证书

原产地证书 (CofO)

Enantioselective hydrogenation of imines using a diverse library of ruthenium dichloride (diphosphine)(diamine) precatalysts
Cobley CJ and Henschke JP
Advanced Synthesis & Catalysis, 345(1-2), 195-201 (2003)
Enantioselective hydrogenation of imines using a diverse library of ruthenium dichloride (diphosphine)(diamine) precatalysts
Cobley CJ and Henschke JP
advanced synthesis and catalysis, 345(1-2), 195-201 (2003)
Asymmetric hydrogenation of a 4, 4-diaryl-3-butenoate; a novel approach to sertraline
Boulton LT, et al.
Organic & Biomolecular Chemistry, 1(7), 1094-1096 (2003)
Asymmetric intramolecular hydrosilylation of hydroxyketones
Burk MJ and Feaster JE
Tetrahedron Letters, 33(16), 2099-2102 (1992)
Asymmetric synthesis of diarylmethanols by Rh (I)-catalyzed arylation of aromatic aldehydes with arylboronic acid
Suzuki K, et al.
Synthesis, 2006(08), 1360-1364 (2006)
技术文章
Asymmetric hydrogenation reactions represent the ideal process for the commercial manufacture of single-enantiomer compounds, because of the ease by which these robust procedures can be scaled up and because of the low levels of byproducts generated in these asymmetric hydrogenations.
了解更多

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

社交媒体

WeChat Icon
Bilibili Icon

默克

研究、开发、生产

作为生命科学行业的全球领先供应商,我们致力于为研究、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. 保留所有权利。

严格禁止在未经同意的情况下转载本网站之所有信息。 Sigma-Aldrich品牌产品均由Sigma-Aldrich LLC.独家贩售。