CN

685062

Sigma-Aldrich

甲氧基(环辛二烯)合铱二聚体

别名:
[Ir(OMe)(1,5-cod)]2, 二(1,5-环辛二烯)二-μ-甲氧基二铱(I)
线性分子式:
[Ir(OCH3)(C8H12)]2
CAS号:
分子量:
662.86
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

reaction suitability

core: iridium
reagent type: catalyst
reaction type: C-H Activation

质量水平

100

mp

154-179 °C (D)

储存温度

−20°C

SMILES string

C[O+]1[Ir-]2[O+](C)[Ir-]12.C3CC=CCCC=C3.C4CC=CCCC=C4

InChI

1S/2C8H12.2CH3O.2Ir/c2*1-2-4-6-8-7-5-3-1;2*1-2;;/h2*1-2,7-8H,3-6H2;2*1H3;;/q;;2*+1;2*-1/b2*2-1-,8-7-;;;;

InChI key

BGWIAAATAAWGOI-MIXQCLKLSA-N

应用

用作以下反应的催化剂:
  • 制备杂芳基稠合的吲哚环体系,作为HCV NS5B聚合酶的抑制剂
  • 硼化反应/Suzuki-Miyaura偶联反应
  • Metalation-Suzuki交叉偶联反应,用于合成联芳基和杂双芳基
  • 四硼化反应
  • 高度区域和对映选择性不对称硼氢化
  • 通过C-H活化使芳基酮、苯甲醛和苄醇衍生物发生邻甲硅烷基化
一种强大的C-H活化催化剂,用于从芳烃制备酚

包装

250 mg in glass bottle
1, 25 g in glass bottle

象形图

Exclamation mark

警示用语:

Warning

危险声明

靶器官

Respiratory system

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Ir?Catalyzed Borylation of C H Bonds in N?Containing Heterocycles: Regioselectivity in the Synthesis of Heteroaryl Boronate Esters.
Mkhalid I, et al.
Angewandte Chemie (International Edition in English), 45(3), 489-491 (2006)
Direct C?H borylation and C?H arylation of pyrrolo [2, 3-d] pyrimidines: synthesis of 6, 8-disubstituted 7-deazapurines.
Klecka M, et al.
Organic & Biomolecular Chemistry, 7(5), 866-868 (2009)
Catalytic functionalization of unactivated primary C?H bonds directed by an alcohol.
Simmons E, et al.
Nature, 483(7387), 70-70 (2012)
A general strategy for the perfluoroalkylation of arenes and arylbromides by using arylboronate esters and [(phen) CuRF].
Litvinas N, et al.
Angewandte Chemie (International Edition in English), 51(2), 536-539 (2012)
Robert E Maleczka et al.
Journal of the American Chemical Society, 125(26), 7792-7793 (2003-06-26)
An efficient one-pot C-H activation/borylation/oxidation protocol for the preparation of phenols is described. This method is particularly attractive for the generation of meta-substituted phenols bearing ortho-/para-directing groups, as such substrates are difficult to access by other phenol syntheses.
技术文章
Arylboronic acids and esters are invaluable tools for the chemical community. These powerful reagents are used for a variety of transformations, most notably the Suzuki-Miyaura cross-coupling reaction.
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