Merck
CN

901558

Sigma-Aldrich

来那度胺

≥95%

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别名:
1-氧-4-氨基-2-(2,6-二氧哌啶-3-基)异吲哚, 3-(4-氨基-1,3-二氢-1-氧代-2H-异吲哚-2-基)-2,6-哌啶二酮, 3-(4-氨基-1-氧代异吲哚-2-基)哌啶-2,6-二酮, E3连接酶配体, 用于PROTAC® >研究的配体
Empirical Formula (Hill Notation):
C13H13N3O3
分子量:
259.26
MDL编号:
NACRES:
NA.22

检测方案

≥95%

形式

powder

reaction suitability

reagent type: ligand

mp

265-268  °C

储存温度

2-8°C

SMILES string

O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N

InChI

1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

InChI key

GOTYRUGSSMKFNF-UHFFFAOYSA-N

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此商品
SML2283P0018930571
Lenalidomide ≥95%

Sigma-Aldrich

901558

来那度胺

Lenalidomide ≥98% (HPLC)

Sigma-Aldrich

SML2283

来那度胺

Pomalidomide ≥98% (HPLC)

Sigma-Aldrich

P0018

泊马度胺

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

reaction suitability

reagent type: ligand

reaction suitability

reagent type: ligand

reaction suitability

reagent type: ligand

reaction suitability

-

mp

265-268  °C

mp

-

mp

-

mp

-

应用

来那度胺被证明是一种可与Cereblon(CRBN)蛋白结合的配体。来那度胺和其他沙利度胺衍生物可用于构建用于靶向蛋白质降解和 PROTAC(靶向蛋白降解嵌合体)技术的小分子。 探索 蛋白质降解剂合成砌块,E3连接酶配体-Linker结合物简化了PROTAC的合成和文库生成。

.

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

相关产品

产品编号
说明
价格

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

Repr. 2 - STOT RE 2

靶器官

Blood

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Cell chemical biology, 27(1), 66-73 (2019-12-21)
The PI3K/AKT signaling cascade is one of the most commonly dysregulated pathways in cancer, with over half of tumors exhibiting aberrant AKT activation. Although potent small-molecule AKT inhibitors have entered clinical trials, robust and durable therapeutic responses have not been
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(10), 1914-1930 (2021-06-27)
Human myeloma bone disease (MBD) occurs when malignant plasma cells migrate to the bone marrow and commence inimical interactions with stromal cells, disrupting the skeletal remodeling process. The myeloma cells simultaneously suppress osteoblastic bone formation while promoting excessive osteoclastic resorption.
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Science (New York, N.Y.), 343(6168), 301-305 (2013-12-03)
Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms, but its mechanism of action is unknown. Using quantitative proteomics, we found that lenalidomide causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1
Philip P Chamberlain et al.
Nature structural & molecular biology, 21(9), 803-809 (2014-08-12)
The Cul4-Rbx1-DDB1-Cereblon E3 ubiquitin ligase complex is the target of thalidomide, lenalidomide and pomalidomide, therapeutically important drugs for multiple myeloma and other B-cell malignancies. These drugs directly bind Cereblon (CRBN) and promote the recruitment of substrates Ikaros (IKZF1) and Aiolos
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Targeted protein degradation (TPD) uses small molecules to recruit E3 ubiquitin ligases into the proximity of proteins of interest, inducing ubiquitination-dependent degradation. A major bottleneck in the TPD field is the lack of accessible E3 ligase ligands for developing degraders.

商品

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

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