description
Dehydroepiandrosterone sulfate (sodium salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (700086P-10mg), pkg of 1 × 25 mg (700086P-25mg), pkg of 1 × 50 mg (700086P-50mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
[S](=O)(=O)(O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@](CC3)(C(=O)CC4)C)CC=C2C1)C)O
InChI
1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1
InChI key
CZWCKYRVOZZJNM-USOAJAOKSA-N
General description
DHEA 硫酸盐是脱氢表雄酮（DHEA）的一种代谢产物，通过硫酸转移酶 SULT1A1 和 SULT1E1 催化添加硫酸基团产生，这些酶也催化从雌酮产生硫酸雌酮。DHEA 硫酸盐也可以通过类固醇硫酸酯酶的作用转化回 DHEA。
脱氢表雄酮(DHEA)是一种肾上腺类固醇，广泛存在于人体内。它是DHAE的硫酸酯，由肾上腺和生殖腺合成。DHEAS在网狀带中产生。
Application
使用硫酸DHEA：
- 作为硫酸类固醇，以趋化性测定骨髓(BM)嗜中性粒细胞并检测其对RAC特异性鸟嘌呤核苷酸交换因子的抑制作用(Rac GEF)
- 在质谱分析法中用作内标物
- 用作合成脂质标准物，以在液相色谱-质谱分析(LC-MS)中加入低密度脂蛋白(LDL)样本
Biochem/physiol Actions
硫酸脱氢表雄酮(DHEA)(DHEAS)可调节儿茶酚胺的合成。它可调节神经递质受体，包括γ-氨基丁酸A型受体(GABAA)和 N-甲基-D -天冬氨酸(NMDA)受体。在阿尔茨海默病(AD)′患者的大脑中可发现到低水平的DHAES。
Packaging
5 mL 琥珀色玻璃螺旋盖小瓶（700086P-10mg）
5 mL 琥珀色玻璃螺旋盖小瓶（700086P-25mg）
5 mL 琥珀色玻璃螺旋盖小瓶（700086P-50mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Ana Reis et al.
Journal of lipid research, 54(7), 1812-1824 (2013-05-15)
Lipidome profile of fluids and tissues is a growing field as the role of lipids as signaling molecules is increasingly understood, relying on an effective and representative extraction of the lipids present. A number of solvent systems suitable for lipid
Marco Racchi et al.
CNS drug reviews, 9(1), 21-40 (2003-02-22)
The physiological role of dehydroepiandrosterone (DHEA) and its sulphated ester DHEA(S) has been studied for nearly 2 decades and still eludes final clarification. The major interest in DHEA derives from its unique pattern of activity. Its levels exhibit a dramatic
Joseph S Dillon
Current drug targets. Inflammation and allergy, 4(3), 377-385 (2005-08-17)
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are metabolic intermediates in the production of potent androgens, estrogens and other less well-characterized steroids. DHEA(S) and closely related steroid hormones have a variety of immunological effects both in vitro and in vivo in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 700086P-50MG | 04061835384846 |
| 700086P-25MG | 04061835384839 |
| 700086P-10MG | 04061835384822 |