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Merck
CN

860492P

Avanti

1-磷酸鞘氨醇 (d18:1)

Avanti Research - A Croda Brand

别名:

D-赤-鞘氨醇-1-磷酸盐

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About This Item

经验公式(希尔记法):
C18H38NO5P
CAS号:
分子量:
379.47
UNSPSC代码:
12352211
NACRES:
NA.25

形式

powder

包装

pkg of 1 × 1 mg (860492P-1mg)
pkg of 1 × 25 mg (860492P-25mg)
pkg of 1 × 5 mg (860492P-5mg)

制造商/商品名称

Avanti Research - A Croda Brand

脂质类型

sphingolipids

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O

InChI

1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1

InChI key

DUYSYHSSBDVJSM-KRWOKUGFSA-N

相关类别

一般描述

鞘氨醇-1-磷酸(S1P),一种鞘脂,是重要的细胞代谢产物和动物细胞信号脂质。在酵母和植物中同样存在。鞘氨醇激酶(SPKs)催化从鞘氨醇 合成S1P,同时调节S1P水平。它是神经酰胺分解代谢的终产物,经S1P裂解酶代谢为磷酸乙醇胺和十六碳烯醛。S1P在内皮细胞中产生。

应用

鞘氨醇-1-磷酸(d18:1)用于:
  • 作为高效液相色谱(HPLC)的内标品,定量血浆脂质鞘氨醇-1-磷酸(S1P)
  • 评估其对自身反应性未成熟B细胞的趋化反应
  • 测试其对缺氧缺糖神经元自噬和预处理的影响

生化/生理作用

鞘氨醇-1-磷酸(S1P)是信号分子和细胞内信使,对生理过程至关重要。与骨质疏松症、癌症、动脉粥样硬化和糖尿病的发病机制有关。S1P调节皮肤树突状细胞和角质形成细胞,其抗炎功能可用于治疗特应性皮炎。S1P通过与G蛋白偶联受体(GPCRS)相互作用,协调淋巴、血浆和组织中的T淋巴细胞循环。S1P是鞘氨醇-1-磷酸受体(S1P−5)的高亲和力配体。

包装

5 mL 棕色玻璃螺旋盖小瓶 (860492P-1 mg)
5 mL 棕色玻璃螺旋盖小瓶 (860492P-25 mg)
5 mL 棕色玻璃螺旋盖小瓶 (860492P-5 mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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访问文档库

Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons
Sheng R, et al.
The Journal of Biological Chemistry, 289(30), 20845-20857 (2014)
Collin Tran et al.
Journal of neurochemistry, e14917-e14917 (2019-11-20)
Sphingosine 1-phosphate (S1P) is an essential lipid metabolite that signals through a family of five G protein-coupled receptors, S1PR1-S1PR5, to regulate cell physiology. The multiple sclerosis drug Fingolimod (FTY720) is a potent S1P receptor agonist that causes peripheral lymphopenia. Recent
Suwon Jeon et al.
Journal of lipid research, 61(1), 20-32 (2019-11-07)
Sphingosine 1-phosphate (S1P) lyase is an intracellular enzyme that catalyzes the irreversible degradation of S1P and has been suggested as a therapeutic target for the treatment of psoriasis vulgaris. Because S1P induces differentiation of keratinocytes, we examined whether modulation of
Liao-Liao Hu et al.
Cells, 8(11) (2019-11-17)
CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the
Effects of apolipoprotein M in uremic atherosclerosis
Bosteen MH, et al.
Atherosclerosis, 265(3), 93-101 (2017)

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