推荐产品
形式
powder
包装
pkg of 1 × 10 mg (860501P-10mg)
pkg of 1 × 5 mg (860501P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860501P
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(NC(CCCCCCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
一般描述
C22神经酰胺(d18:1/22:0)或N-山嵛酰-D-赤型-鞘氨醇是一种人工合成的、由鞘氨醇和山嵛酸组成的神经酰胺。
应用
C22神经酰胺(d18:1/22:0)已用于：
- 作为标准品，用于通过高效液相色谱/串联质谱(LC/MS2)技术测定肌肉组织样品中的神经酰胺浓度
- 作为鞘脂代谢物的定量分析标准品
- 研究其对线粒体-胞浆应激反应(MCSR)诱发的影响
生化/生理作用
神经酰胺在细胞分化、增殖和凋亡调节中起重要作用。还能调节应激和炎症反应。
包装
5 mL棕色玻璃螺旋盖样品瓶（860501P-10mg）
5 mL棕色玻璃螺旋盖样品瓶（860501P-5mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Hyun-Eui Kim et al.
Cell, 166(6), 1539-1552 (2016-09-10)
Defects in mitochondrial metabolism have been increasingly linked with age-onset protein-misfolding diseases such as Alzheimer's, Parkinson's, and Huntington's. In response to protein-folding stress, compartment-specific unfolded protein responses (UPRs) within the ER, mitochondria, and cytosol work in parallel to ensure cellular
Mutay Aslan et al.
Nutrition and cancer, 1-13 (2020-04-15)
We aimed to investigate the impact of thymoquinone (TQ), on sphingolipid metabolites, ER stress and apoptotic pathways in MCF-7 and HepG2 cancer cells. Antiproliferative effect was exerted in cancer cells via TQ incubation at different doses and durations. Cell viability
Xingzhong Zhang et al.
Cell metabolism, 30(5), 937-951 (2019-11-02)
Obesity-induced adipose dysfunction is a major contributor to atherosclerosis. Cold exposure has been reported to affect atherosclerosis through regulation of adipose function, but the mechanism has not been well clarified. Here, adipocyte hypoxia-inducible factor 2α (HIF-2α) was upregulated after mild cold
Dimple Kauhanen et al.
Analytical and bioanalytical chemistry, 408(13), 3475-3483 (2016-02-29)
Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease (CAD). We describe a validated liquid chromatography-tandem mass spectrometry
Ebru Afşar et al.
Redox biology, 30, 101430-101430 (2020-01-25)
We aimed to determine sphingolipid levels and examine apoptotic pathways in human retinal pigment epithelial cells (ARPE-19) undergoing endoplasmic reticulum (ER) stress. Cells were treated with tunicamycin (TM) to induce ER stress and tauroursodeoxycholic acid (TUDCA), an ER stress inhibitor
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